SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia

The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined. The involvement of microRNA (miRNA) is actually helping to shed light on an important issue in the occurrence of myeloproliferative neoplasms (MPNs). However,...

Descripción completa

Detalles Bibliográficos
Autores principales: Albano, Francesco, Anelli, Luisa, Zagaria, Antonella, Coccaro, Nicoletta, Casieri, Paola, Minervini, Angela, Specchia, Giorgina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470981/
https://www.ncbi.nlm.nih.gov/pubmed/22873195
http://dx.doi.org/10.1186/1756-8722-5-48
_version_ 1782246347877908480
author Albano, Francesco
Anelli, Luisa
Zagaria, Antonella
Coccaro, Nicoletta
Casieri, Paola
Minervini, Angela
Specchia, Giorgina
author_facet Albano, Francesco
Anelli, Luisa
Zagaria, Antonella
Coccaro, Nicoletta
Casieri, Paola
Minervini, Angela
Specchia, Giorgina
author_sort Albano, Francesco
collection PubMed
description The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined. The involvement of microRNA (miRNA) is actually helping to shed light on an important issue in the occurrence of myeloproliferative neoplasms (MPNs). However, the role of intronic miRNA, derived from the intron regions of gene transcripts, has never been reported in MPNs. In this study, we describe a PMF case evolved to AML with a t(12;18)(p13;q12) rearrangement showing the downregulation of the intronic miR_4319 and the overexpression of its host gene, SET binding protein (SETBP1). A possible molecular mechanism regulating the PMF progression to AML is discussed.
format Online
Article
Text
id pubmed-3470981
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-34709812012-10-16 SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia Albano, Francesco Anelli, Luisa Zagaria, Antonella Coccaro, Nicoletta Casieri, Paola Minervini, Angela Specchia, Giorgina J Hematol Oncol Letter to the Editor The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined. The involvement of microRNA (miRNA) is actually helping to shed light on an important issue in the occurrence of myeloproliferative neoplasms (MPNs). However, the role of intronic miRNA, derived from the intron regions of gene transcripts, has never been reported in MPNs. In this study, we describe a PMF case evolved to AML with a t(12;18)(p13;q12) rearrangement showing the downregulation of the intronic miR_4319 and the overexpression of its host gene, SET binding protein (SETBP1). A possible molecular mechanism regulating the PMF progression to AML is discussed. BioMed Central 2012-08-08 /pmc/articles/PMC3470981/ /pubmed/22873195 http://dx.doi.org/10.1186/1756-8722-5-48 Text en Copyright ©2012 Albano et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Albano, Francesco
Anelli, Luisa
Zagaria, Antonella
Coccaro, Nicoletta
Casieri, Paola
Minervini, Angela
Specchia, Giorgina
SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia
title SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia
title_full SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia
title_fullStr SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia
title_full_unstemmed SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia
title_short SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia
title_sort setbp1 and mir_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470981/
https://www.ncbi.nlm.nih.gov/pubmed/22873195
http://dx.doi.org/10.1186/1756-8722-5-48
work_keys_str_mv AT albanofrancesco setbp1andmir4319dysregulationinprimarymyelofibrosisprogressiontoacutemyeloidleukemia
AT anelliluisa setbp1andmir4319dysregulationinprimarymyelofibrosisprogressiontoacutemyeloidleukemia
AT zagariaantonella setbp1andmir4319dysregulationinprimarymyelofibrosisprogressiontoacutemyeloidleukemia
AT coccaronicoletta setbp1andmir4319dysregulationinprimarymyelofibrosisprogressiontoacutemyeloidleukemia
AT casieripaola setbp1andmir4319dysregulationinprimarymyelofibrosisprogressiontoacutemyeloidleukemia
AT minerviniangela setbp1andmir4319dysregulationinprimarymyelofibrosisprogressiontoacutemyeloidleukemia
AT specchiagiorgina setbp1andmir4319dysregulationinprimarymyelofibrosisprogressiontoacutemyeloidleukemia

Ejemplares similares