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Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols

BACKGROUND: The mechanisms responsible for chemoresistance in patients with refractory classical Hodgkin lymphoma (CHL) are unknown. ATP-binding cassette (ABC) transporters confer multidrug resistance in various cancers and ABCC1 overexpression has been shown to contribute to drug resistance in the...

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Autores principales: Greaves, Wesley, Xiao, Lianchun, Sanchez-Espiridion, Beatriz, Kunkalla, Kranthi, Dave, Kunal S, Liang, Cynthia S, Singh, Rajesh R, Younes, Anas, Medeiros, L Jeffrey, Vega, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470996/
https://www.ncbi.nlm.nih.gov/pubmed/22871336
http://dx.doi.org/10.1186/1756-8722-5-47
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author Greaves, Wesley
Xiao, Lianchun
Sanchez-Espiridion, Beatriz
Kunkalla, Kranthi
Dave, Kunal S
Liang, Cynthia S
Singh, Rajesh R
Younes, Anas
Medeiros, L Jeffrey
Vega, Francisco
author_facet Greaves, Wesley
Xiao, Lianchun
Sanchez-Espiridion, Beatriz
Kunkalla, Kranthi
Dave, Kunal S
Liang, Cynthia S
Singh, Rajesh R
Younes, Anas
Medeiros, L Jeffrey
Vega, Francisco
author_sort Greaves, Wesley
collection PubMed
description BACKGROUND: The mechanisms responsible for chemoresistance in patients with refractory classical Hodgkin lymphoma (CHL) are unknown. ATP-binding cassette (ABC) transporters confer multidrug resistance in various cancers and ABCC1 overexpression has been shown to contribute to drug resistance in the CHL cell line, KMH2. FINDINGS: We analyzed for expression of five ABC transporters ABCB1, ABCC1, ABCC2, ABCC3 and ABCG2 using immunohistochemistry in 103 pre-treatment tumor specimens obtained from patients with CHL. All patients received first-line standard chemotherapy with doxorubicin (Adriamycin®), bleomycin, vinblastine, and dacarbazine (ABVD) or equivalent regimens. ABCC1 was expressed in Hodgkin and Reed-Sternberg (HRS) cells in 16 of 82 cases (19.5%) and ABCG2 was expressed by HRS cells in 25 of 77 cases (32.5%). All tumors were negative for ABCB1, ABCC2 and ABCC3. ABCC1 expression was associated with refractory disease (p = 0.01) and was marginally associated with poorer failure-free survival (p = 0.06). Multivariate analysis after adjusting for hemoglobin and albumin levels and age showed that patients with CHL with HRS cells positive for ABCC1 had a higher risk of not responding to treatment (HR = 2.84, 95%, CI: 1.12-7.19 p = 0.028). CONCLUSIONS: Expression of ABCC1 by HRS cells in CHL patients predicts a higher risk of treatment failure and is marginally associated with poorer failure-free survival using standard frontline chemotherapy regimens.
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spelling pubmed-34709962012-10-16 Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols Greaves, Wesley Xiao, Lianchun Sanchez-Espiridion, Beatriz Kunkalla, Kranthi Dave, Kunal S Liang, Cynthia S Singh, Rajesh R Younes, Anas Medeiros, L Jeffrey Vega, Francisco J Hematol Oncol Rapid Communication BACKGROUND: The mechanisms responsible for chemoresistance in patients with refractory classical Hodgkin lymphoma (CHL) are unknown. ATP-binding cassette (ABC) transporters confer multidrug resistance in various cancers and ABCC1 overexpression has been shown to contribute to drug resistance in the CHL cell line, KMH2. FINDINGS: We analyzed for expression of five ABC transporters ABCB1, ABCC1, ABCC2, ABCC3 and ABCG2 using immunohistochemistry in 103 pre-treatment tumor specimens obtained from patients with CHL. All patients received first-line standard chemotherapy with doxorubicin (Adriamycin®), bleomycin, vinblastine, and dacarbazine (ABVD) or equivalent regimens. ABCC1 was expressed in Hodgkin and Reed-Sternberg (HRS) cells in 16 of 82 cases (19.5%) and ABCG2 was expressed by HRS cells in 25 of 77 cases (32.5%). All tumors were negative for ABCB1, ABCC2 and ABCC3. ABCC1 expression was associated with refractory disease (p = 0.01) and was marginally associated with poorer failure-free survival (p = 0.06). Multivariate analysis after adjusting for hemoglobin and albumin levels and age showed that patients with CHL with HRS cells positive for ABCC1 had a higher risk of not responding to treatment (HR = 2.84, 95%, CI: 1.12-7.19 p = 0.028). CONCLUSIONS: Expression of ABCC1 by HRS cells in CHL patients predicts a higher risk of treatment failure and is marginally associated with poorer failure-free survival using standard frontline chemotherapy regimens. BioMed Central 2012-08-07 /pmc/articles/PMC3470996/ /pubmed/22871336 http://dx.doi.org/10.1186/1756-8722-5-47 Text en Copyright ©2012 Greaves et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Rapid Communication
Greaves, Wesley
Xiao, Lianchun
Sanchez-Espiridion, Beatriz
Kunkalla, Kranthi
Dave, Kunal S
Liang, Cynthia S
Singh, Rajesh R
Younes, Anas
Medeiros, L Jeffrey
Vega, Francisco
Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols
title Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols
title_full Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols
title_fullStr Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols
title_full_unstemmed Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols
title_short Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols
title_sort detection of abcc1 expression in classical hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470996/
https://www.ncbi.nlm.nih.gov/pubmed/22871336
http://dx.doi.org/10.1186/1756-8722-5-47
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