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Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection
Helicobacter pylori infection induces chronic inflammation which is characterized not only by infiltrations of inflammatory cells such as neutrophils and CD4(+) T cells, but also significant populations of regulatory T cells (T(reg)). These cells are important for disease pathogenesis because they a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470998/ https://www.ncbi.nlm.nih.gov/pubmed/23087691 http://dx.doi.org/10.3389/fimmu.2012.00316 |
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author | Walduck, Anna K. Becher, Dorit |
author_facet | Walduck, Anna K. Becher, Dorit |
author_sort | Walduck, Anna K. |
collection | PubMed |
description | Helicobacter pylori infection induces chronic inflammation which is characterized not only by infiltrations of inflammatory cells such as neutrophils and CD4(+) T cells, but also significant populations of regulatory T cells (T(reg)). These cells are important for disease pathogenesis because they are believed to contribute to the persistence of the infection. Despite encouraging results in animal models, the prospects for an effective H. pylori vaccine are currently poor because of generally disappointing results in preclinical and phase 1 trials. As a result, a current major focus of basic research on vaccination is to better understand the mechanisms regulating the inflammatory response with the view it can inform future vaccine design. Our studies in this area have focused on gastric CD4(+) T(reg) in vaccinated mice, and raised the hypothesis that adipokines in particular leptin are involved the establishment of a protective gastric immune response. Here we discuss the hypothesis that vaccination deregulates T(reg) responses in the gastric mucosa, and that this process is mediated by leptin. We propose that reduced suppression permits a protective sub population of H. pylori-specific CD4(+) T cells to exert protective effects, presumably via the gastric epithelium. Evidence from the literature and experimental approaches will be discussed. |
format | Online Article Text |
id | pubmed-3470998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-34709982012-10-19 Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection Walduck, Anna K. Becher, Dorit Front Immunol Immunology Helicobacter pylori infection induces chronic inflammation which is characterized not only by infiltrations of inflammatory cells such as neutrophils and CD4(+) T cells, but also significant populations of regulatory T cells (T(reg)). These cells are important for disease pathogenesis because they are believed to contribute to the persistence of the infection. Despite encouraging results in animal models, the prospects for an effective H. pylori vaccine are currently poor because of generally disappointing results in preclinical and phase 1 trials. As a result, a current major focus of basic research on vaccination is to better understand the mechanisms regulating the inflammatory response with the view it can inform future vaccine design. Our studies in this area have focused on gastric CD4(+) T(reg) in vaccinated mice, and raised the hypothesis that adipokines in particular leptin are involved the establishment of a protective gastric immune response. Here we discuss the hypothesis that vaccination deregulates T(reg) responses in the gastric mucosa, and that this process is mediated by leptin. We propose that reduced suppression permits a protective sub population of H. pylori-specific CD4(+) T cells to exert protective effects, presumably via the gastric epithelium. Evidence from the literature and experimental approaches will be discussed. Frontiers Media S.A. 2012-10-15 /pmc/articles/PMC3470998/ /pubmed/23087691 http://dx.doi.org/10.3389/fimmu.2012.00316 Text en Copyright © Walduck and Becher. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Immunology Walduck, Anna K. Becher, Dorit Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection |
title | Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection |
title_full | Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection |
title_fullStr | Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection |
title_full_unstemmed | Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection |
title_short | Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection |
title_sort | leptin, cd4(+) t(reg) and the prospects for vaccination against h. pylori infection |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470998/ https://www.ncbi.nlm.nih.gov/pubmed/23087691 http://dx.doi.org/10.3389/fimmu.2012.00316 |
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