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Bone Marrow Microenvironment in Multiple Myeloma Progression
Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant pl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471001/ https://www.ncbi.nlm.nih.gov/pubmed/23093834 http://dx.doi.org/10.1155/2012/157496 |
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author | Manier, S. Sacco, A. Leleu, X. Ghobrial, I. M. Roccaro, A. M. |
author_facet | Manier, S. Sacco, A. Leleu, X. Ghobrial, I. M. Roccaro, A. M. |
author_sort | Manier, S. |
collection | PubMed |
description | Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellular matrix (ECM) and the liquid milieu (cytokines, growth factors, and chemokines). In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche. |
format | Online Article Text |
id | pubmed-3471001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34710012012-10-23 Bone Marrow Microenvironment in Multiple Myeloma Progression Manier, S. Sacco, A. Leleu, X. Ghobrial, I. M. Roccaro, A. M. J Biomed Biotechnol Review Article Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellular matrix (ECM) and the liquid milieu (cytokines, growth factors, and chemokines). In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche. Hindawi Publishing Corporation 2012 2012-10-03 /pmc/articles/PMC3471001/ /pubmed/23093834 http://dx.doi.org/10.1155/2012/157496 Text en Copyright © 2012 S. Manier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Manier, S. Sacco, A. Leleu, X. Ghobrial, I. M. Roccaro, A. M. Bone Marrow Microenvironment in Multiple Myeloma Progression |
title | Bone Marrow Microenvironment in Multiple Myeloma Progression |
title_full | Bone Marrow Microenvironment in Multiple Myeloma Progression |
title_fullStr | Bone Marrow Microenvironment in Multiple Myeloma Progression |
title_full_unstemmed | Bone Marrow Microenvironment in Multiple Myeloma Progression |
title_short | Bone Marrow Microenvironment in Multiple Myeloma Progression |
title_sort | bone marrow microenvironment in multiple myeloma progression |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471001/ https://www.ncbi.nlm.nih.gov/pubmed/23093834 http://dx.doi.org/10.1155/2012/157496 |
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