Cargando…

Bone Marrow Microenvironment in Multiple Myeloma Progression

Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant pl...

Descripción completa

Detalles Bibliográficos
Autores principales: Manier, S., Sacco, A., Leleu, X., Ghobrial, I. M., Roccaro, A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471001/
https://www.ncbi.nlm.nih.gov/pubmed/23093834
http://dx.doi.org/10.1155/2012/157496
_version_ 1782246353560141824
author Manier, S.
Sacco, A.
Leleu, X.
Ghobrial, I. M.
Roccaro, A. M.
author_facet Manier, S.
Sacco, A.
Leleu, X.
Ghobrial, I. M.
Roccaro, A. M.
author_sort Manier, S.
collection PubMed
description Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellular matrix (ECM) and the liquid milieu (cytokines, growth factors, and chemokines). In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche.
format Online
Article
Text
id pubmed-3471001
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-34710012012-10-23 Bone Marrow Microenvironment in Multiple Myeloma Progression Manier, S. Sacco, A. Leleu, X. Ghobrial, I. M. Roccaro, A. M. J Biomed Biotechnol Review Article Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellular matrix (ECM) and the liquid milieu (cytokines, growth factors, and chemokines). In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche. Hindawi Publishing Corporation 2012 2012-10-03 /pmc/articles/PMC3471001/ /pubmed/23093834 http://dx.doi.org/10.1155/2012/157496 Text en Copyright © 2012 S. Manier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Manier, S.
Sacco, A.
Leleu, X.
Ghobrial, I. M.
Roccaro, A. M.
Bone Marrow Microenvironment in Multiple Myeloma Progression
title Bone Marrow Microenvironment in Multiple Myeloma Progression
title_full Bone Marrow Microenvironment in Multiple Myeloma Progression
title_fullStr Bone Marrow Microenvironment in Multiple Myeloma Progression
title_full_unstemmed Bone Marrow Microenvironment in Multiple Myeloma Progression
title_short Bone Marrow Microenvironment in Multiple Myeloma Progression
title_sort bone marrow microenvironment in multiple myeloma progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471001/
https://www.ncbi.nlm.nih.gov/pubmed/23093834
http://dx.doi.org/10.1155/2012/157496
work_keys_str_mv AT maniers bonemarrowmicroenvironmentinmultiplemyelomaprogression
AT saccoa bonemarrowmicroenvironmentinmultiplemyelomaprogression
AT leleux bonemarrowmicroenvironmentinmultiplemyelomaprogression
AT ghobrialim bonemarrowmicroenvironmentinmultiplemyelomaprogression
AT roccaroam bonemarrowmicroenvironmentinmultiplemyelomaprogression