Automated and fast building of three-dimensional RNA structures

Building tertiary structures of non-coding RNA is required to understand their functions and design new molecules. Current algorithms of RNA tertiary structure prediction give satisfactory accuracy only for small size and simple topology and many of them need manual manipulation. Here, we present an...

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Detalles Bibliográficos
Autores principales: Zhao, Yunjie, Huang, Yangyu, Gong, Zhou, Wang, Yanjie, Man, Jianfen, Xiao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471093/
https://www.ncbi.nlm.nih.gov/pubmed/23071898
http://dx.doi.org/10.1038/srep00734
Descripción
Sumario:Building tertiary structures of non-coding RNA is required to understand their functions and design new molecules. Current algorithms of RNA tertiary structure prediction give satisfactory accuracy only for small size and simple topology and many of them need manual manipulation. Here, we present an automated and fast program,3dRNA, for RNA tertiary structure prediction with reasonable accuracy for RNAs of larger size and complex topology.

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