Guilt by association: What p120-catenin has to hide

Members of the p120-catenin family associate with cadherins and regulate their stability at the plasma membrane. How p120-catenin limits cadherin endocytosis has long remained a mystery. In this issue, Nanes et al. (2012. J. Cell Biol. doi:10.1083/jcb.201205029) identify a conserved acidic motif wit...

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Detalles Bibliográficos
Autores principales: Perez-Moreno, Mirna, Fuchs, Elaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471234/
https://www.ncbi.nlm.nih.gov/pubmed/23071151
http://dx.doi.org/10.1083/jcb.201209014
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author Perez-Moreno, Mirna
Fuchs, Elaine
author_facet Perez-Moreno, Mirna
Fuchs, Elaine
author_sort Perez-Moreno, Mirna
collection PubMed
description Members of the p120-catenin family associate with cadherins and regulate their stability at the plasma membrane. How p120-catenin limits cadherin endocytosis has long remained a mystery. In this issue, Nanes et al. (2012. J. Cell Biol. doi:10.1083/jcb.201205029) identify a conserved acidic motif within cadherins that acts as a physical platform for p120-catenin binding. However, in the absence of p120-catenin, the motif acts as an endocytic signal. These results provide new insight into p120-catenin’s role as guardian of intercellular junction dynamics.
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spelling pubmed-34712342013-04-15 Guilt by association: What p120-catenin has to hide Perez-Moreno, Mirna Fuchs, Elaine J Cell Biol Reviews Members of the p120-catenin family associate with cadherins and regulate their stability at the plasma membrane. How p120-catenin limits cadherin endocytosis has long remained a mystery. In this issue, Nanes et al. (2012. J. Cell Biol. doi:10.1083/jcb.201205029) identify a conserved acidic motif within cadherins that acts as a physical platform for p120-catenin binding. However, in the absence of p120-catenin, the motif acts as an endocytic signal. These results provide new insight into p120-catenin’s role as guardian of intercellular junction dynamics. The Rockefeller University Press 2012-10-15 /pmc/articles/PMC3471234/ /pubmed/23071151 http://dx.doi.org/10.1083/jcb.201209014 Text en © 2012 Perez-Moreno and Fuchs This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Perez-Moreno, Mirna
Fuchs, Elaine
Guilt by association: What p120-catenin has to hide
title Guilt by association: What p120-catenin has to hide
title_full Guilt by association: What p120-catenin has to hide
title_fullStr Guilt by association: What p120-catenin has to hide
title_full_unstemmed Guilt by association: What p120-catenin has to hide
title_short Guilt by association: What p120-catenin has to hide
title_sort guilt by association: what p120-catenin has to hide
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471234/
https://www.ncbi.nlm.nih.gov/pubmed/23071151
http://dx.doi.org/10.1083/jcb.201209014
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