Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer

Genetic defects in breast cancer (BC) susceptibility genes, most importantly BRCA1 and BRCA2, account for ∼40% of hereditary BC and ovarian cancer (OC). Little is known about the contribution of constitutive (soma-wide) epimutations to the remaining cases. We developed bisulfite pyrosequencing assay...

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Detalles Bibliográficos
Autores principales: Hansmann, Tamara, Pliushch, Galyna, Leubner, Monika, Kroll, Patricia, Endt, Daniela, Gehrig, Andrea, Preisler-Adams, Sabine, Wieacker, Peter, Haaf, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471399/
https://www.ncbi.nlm.nih.gov/pubmed/22843497
http://dx.doi.org/10.1093/hmg/dds308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471399/
https://www.ncbi.nlm.nih.gov/pubmed/22843497
http://dx.doi.org/10.1093/hmg/dds308

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