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Radiation Therapy for Locally Recurrent Breast Cancer

Approximately one-third of all breast cancer patients experience local recurrence of their tumor after initial treatment. As initial treatment often employs the use of radiation therapy (RT), the standard of care for local breast cancer recurrence after initial breast conserving therapy has traditio...

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Autores principales: Siglin, Joshua, Champ, Colin E., Vakhnenko, Yelena, Anne, Pramila R., Simone, Nicole L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471452/
https://www.ncbi.nlm.nih.gov/pubmed/23091733
http://dx.doi.org/10.1155/2012/571946
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author Siglin, Joshua
Champ, Colin E.
Vakhnenko, Yelena
Anne, Pramila R.
Simone, Nicole L.
author_facet Siglin, Joshua
Champ, Colin E.
Vakhnenko, Yelena
Anne, Pramila R.
Simone, Nicole L.
author_sort Siglin, Joshua
collection PubMed
description Approximately one-third of all breast cancer patients experience local recurrence of their tumor after initial treatment. As initial treatment often employs the use of radiation therapy (RT), the standard of care for local breast cancer recurrence after initial breast conserving therapy has traditionally been surgical intervention with mastectomy. However, recent attempts to preserve the intact breast after recurrence with local excision have revealed a potential need for RT in addition to repeat breast conserving surgery as rates of local failure with resection alone remain high. Additionally, local recurrence following initial mastectomy and chest wall RT can be treated with reirradiation to increase local control. Repeating RT, however, in a previously irradiated area, is a complex treatment strategy, as the clinician must carefully balance maximizing treatment effectiveness while minimizing treatment-related toxicity. As a result, physicians have been hesitant to treat recurrent disease with repeat RT with limited data. Results from the current literature are promising and current clinical trials are underway to explore reirradiation modalities which will provide additional information on treatment-related toxicity and outcomes. This paper will review the current literature on repeat radiation therapy for locally recurrent breast cancer.
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spelling pubmed-34714522012-10-22 Radiation Therapy for Locally Recurrent Breast Cancer Siglin, Joshua Champ, Colin E. Vakhnenko, Yelena Anne, Pramila R. Simone, Nicole L. Int J Breast Cancer Review Article Approximately one-third of all breast cancer patients experience local recurrence of their tumor after initial treatment. As initial treatment often employs the use of radiation therapy (RT), the standard of care for local breast cancer recurrence after initial breast conserving therapy has traditionally been surgical intervention with mastectomy. However, recent attempts to preserve the intact breast after recurrence with local excision have revealed a potential need for RT in addition to repeat breast conserving surgery as rates of local failure with resection alone remain high. Additionally, local recurrence following initial mastectomy and chest wall RT can be treated with reirradiation to increase local control. Repeating RT, however, in a previously irradiated area, is a complex treatment strategy, as the clinician must carefully balance maximizing treatment effectiveness while minimizing treatment-related toxicity. As a result, physicians have been hesitant to treat recurrent disease with repeat RT with limited data. Results from the current literature are promising and current clinical trials are underway to explore reirradiation modalities which will provide additional information on treatment-related toxicity and outcomes. This paper will review the current literature on repeat radiation therapy for locally recurrent breast cancer. Hindawi Publishing Corporation 2012 2012-10-03 /pmc/articles/PMC3471452/ /pubmed/23091733 http://dx.doi.org/10.1155/2012/571946 Text en Copyright © 2012 Joshua Siglin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Siglin, Joshua
Champ, Colin E.
Vakhnenko, Yelena
Anne, Pramila R.
Simone, Nicole L.
Radiation Therapy for Locally Recurrent Breast Cancer
title Radiation Therapy for Locally Recurrent Breast Cancer
title_full Radiation Therapy for Locally Recurrent Breast Cancer
title_fullStr Radiation Therapy for Locally Recurrent Breast Cancer
title_full_unstemmed Radiation Therapy for Locally Recurrent Breast Cancer
title_short Radiation Therapy for Locally Recurrent Breast Cancer
title_sort radiation therapy for locally recurrent breast cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471452/
https://www.ncbi.nlm.nih.gov/pubmed/23091733
http://dx.doi.org/10.1155/2012/571946
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