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Radiation Therapy for Locally Recurrent Breast Cancer
Approximately one-third of all breast cancer patients experience local recurrence of their tumor after initial treatment. As initial treatment often employs the use of radiation therapy (RT), the standard of care for local breast cancer recurrence after initial breast conserving therapy has traditio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471452/ https://www.ncbi.nlm.nih.gov/pubmed/23091733 http://dx.doi.org/10.1155/2012/571946 |
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author | Siglin, Joshua Champ, Colin E. Vakhnenko, Yelena Anne, Pramila R. Simone, Nicole L. |
author_facet | Siglin, Joshua Champ, Colin E. Vakhnenko, Yelena Anne, Pramila R. Simone, Nicole L. |
author_sort | Siglin, Joshua |
collection | PubMed |
description | Approximately one-third of all breast cancer patients experience local recurrence of their tumor after initial treatment. As initial treatment often employs the use of radiation therapy (RT), the standard of care for local breast cancer recurrence after initial breast conserving therapy has traditionally been surgical intervention with mastectomy. However, recent attempts to preserve the intact breast after recurrence with local excision have revealed a potential need for RT in addition to repeat breast conserving surgery as rates of local failure with resection alone remain high. Additionally, local recurrence following initial mastectomy and chest wall RT can be treated with reirradiation to increase local control. Repeating RT, however, in a previously irradiated area, is a complex treatment strategy, as the clinician must carefully balance maximizing treatment effectiveness while minimizing treatment-related toxicity. As a result, physicians have been hesitant to treat recurrent disease with repeat RT with limited data. Results from the current literature are promising and current clinical trials are underway to explore reirradiation modalities which will provide additional information on treatment-related toxicity and outcomes. This paper will review the current literature on repeat radiation therapy for locally recurrent breast cancer. |
format | Online Article Text |
id | pubmed-3471452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34714522012-10-22 Radiation Therapy for Locally Recurrent Breast Cancer Siglin, Joshua Champ, Colin E. Vakhnenko, Yelena Anne, Pramila R. Simone, Nicole L. Int J Breast Cancer Review Article Approximately one-third of all breast cancer patients experience local recurrence of their tumor after initial treatment. As initial treatment often employs the use of radiation therapy (RT), the standard of care for local breast cancer recurrence after initial breast conserving therapy has traditionally been surgical intervention with mastectomy. However, recent attempts to preserve the intact breast after recurrence with local excision have revealed a potential need for RT in addition to repeat breast conserving surgery as rates of local failure with resection alone remain high. Additionally, local recurrence following initial mastectomy and chest wall RT can be treated with reirradiation to increase local control. Repeating RT, however, in a previously irradiated area, is a complex treatment strategy, as the clinician must carefully balance maximizing treatment effectiveness while minimizing treatment-related toxicity. As a result, physicians have been hesitant to treat recurrent disease with repeat RT with limited data. Results from the current literature are promising and current clinical trials are underway to explore reirradiation modalities which will provide additional information on treatment-related toxicity and outcomes. This paper will review the current literature on repeat radiation therapy for locally recurrent breast cancer. Hindawi Publishing Corporation 2012 2012-10-03 /pmc/articles/PMC3471452/ /pubmed/23091733 http://dx.doi.org/10.1155/2012/571946 Text en Copyright © 2012 Joshua Siglin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Siglin, Joshua Champ, Colin E. Vakhnenko, Yelena Anne, Pramila R. Simone, Nicole L. Radiation Therapy for Locally Recurrent Breast Cancer |
title | Radiation Therapy for Locally Recurrent Breast Cancer |
title_full | Radiation Therapy for Locally Recurrent Breast Cancer |
title_fullStr | Radiation Therapy for Locally Recurrent Breast Cancer |
title_full_unstemmed | Radiation Therapy for Locally Recurrent Breast Cancer |
title_short | Radiation Therapy for Locally Recurrent Breast Cancer |
title_sort | radiation therapy for locally recurrent breast cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471452/ https://www.ncbi.nlm.nih.gov/pubmed/23091733 http://dx.doi.org/10.1155/2012/571946 |
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