Cargando…
Centrosome Aberrations Associated with Cellular Senescence and p53 Localization at Supernumerary Centrosomes
Centrosome overduplication or amplification has been observed in many human cancers and in premalignant tissue, but the mechanisms leading to such centrosome aberrations are not fully understood. We previously showed that abnormal mitotic cells with supernumerary centrosomes increase with replicativ...
Autor principal: | Ohshima, Susumu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471474/ https://www.ncbi.nlm.nih.gov/pubmed/23091651 http://dx.doi.org/10.1155/2012/217594 |
Ejemplares similares
-
The PIDDosome activates p53 in response to supernumerary centrosomes
por: Fava, Luca L., et al.
Publicado: (2017) -
Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes
por: Navarro-Serer, Bernat, et al.
Publicado: (2019) -
p53 censuses centrosomes
por: Leslie, Mitch
Publicado: (2015) -
p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway
por: Contadini, Claudia, et al.
Publicado: (2019) -
KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells
por: Mashima, Yu, et al.
Publicado: (2022)