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Oversulfated Chondroitin Sulfate Inhibits the Complement Classical Pathway by Potentiating C1 Inhibitor

Oversulfated chondroitin sulfate (OSCS) has become the subject of multidisciplinary investigation as a non-traditional contaminant in the heparin therapeutic preparations that were linked to severe adverse events. In this study, it was found that OSCS inhibited complement fixation on bacteria and ba...

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Detalles Bibliográficos
Autores principales: Zhou, Zhao-Hua, Rajabi, Mohsen, Chen, Trina, Karnaukhova, Elena, Kozlowski, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471833/
https://www.ncbi.nlm.nih.gov/pubmed/23077587
http://dx.doi.org/10.1371/journal.pone.0047296