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Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study

OBJECTIVES: Precise mechanisms of atrial fibrillation (AF) are uncertain, but their association with esophageal disorders has been recently proposed. The association between gastroesophageal reflux disease (GERD), the most common gastroesophageal disorder, and AF remains undetermined. We therefore a...

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Autores principales: Huang, Chin-Chou, Chan, Wan-Leong, Luo, Jiing-Chyuan, Chen, Yu-Chun, Chen, Tzeng-Ji, Chung, Chia-Min, Huang, Po-Hsun, Lin, Shing-Jong, Chen, Jaw-Wen, Leu, Hsin-Bang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471851/
https://www.ncbi.nlm.nih.gov/pubmed/23077642
http://dx.doi.org/10.1371/journal.pone.0047575
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author Huang, Chin-Chou
Chan, Wan-Leong
Luo, Jiing-Chyuan
Chen, Yu-Chun
Chen, Tzeng-Ji
Chung, Chia-Min
Huang, Po-Hsun
Lin, Shing-Jong
Chen, Jaw-Wen
Leu, Hsin-Bang
author_facet Huang, Chin-Chou
Chan, Wan-Leong
Luo, Jiing-Chyuan
Chen, Yu-Chun
Chen, Tzeng-Ji
Chung, Chia-Min
Huang, Po-Hsun
Lin, Shing-Jong
Chen, Jaw-Wen
Leu, Hsin-Bang
author_sort Huang, Chin-Chou
collection PubMed
description OBJECTIVES: Precise mechanisms of atrial fibrillation (AF) are uncertain, but their association with esophageal disorders has been recently proposed. The association between gastroesophageal reflux disease (GERD), the most common gastroesophageal disorder, and AF remains undetermined. We therefore aimed to investigate the association between GERD and later development of AF. METHODS AND RESULTS: Patients with GERD were identified from the 1,000,000-person cohort dataset sampled from the Taiwan National Health Insurance database. The study cohort comprised 29,688 newly diagnosed adult GERD patients; 29,597 randomly selected age-, gender-, comobidity-matched subjects comprised the comparison cohort. Cox proportional hazard regressions were performed as a means of comparing the AF-free survival rate for the two cohorts. During a maximum three years of follow-up, a total of 351 patients experienced AF, including 184 (0.62%) patients in the GERD cohort and 167 (0.56%) in the control group. The log-rank test showed that patients with GERD had significantly higher incidence of AF than those without GERD (p = 0.024). After Cox proportional hazard regression model analysis, GERD was independently associated with the increased risk of AF (hazard ratio, 1.31; 95% confidence interval, 1.06–1.61, p = 0.013). CONCLUSION: GERD was independently associated with an increased risk of future AF in a nationwide population-based cohort.
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spelling pubmed-34718512012-10-17 Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study Huang, Chin-Chou Chan, Wan-Leong Luo, Jiing-Chyuan Chen, Yu-Chun Chen, Tzeng-Ji Chung, Chia-Min Huang, Po-Hsun Lin, Shing-Jong Chen, Jaw-Wen Leu, Hsin-Bang PLoS One Research Article OBJECTIVES: Precise mechanisms of atrial fibrillation (AF) are uncertain, but their association with esophageal disorders has been recently proposed. The association between gastroesophageal reflux disease (GERD), the most common gastroesophageal disorder, and AF remains undetermined. We therefore aimed to investigate the association between GERD and later development of AF. METHODS AND RESULTS: Patients with GERD were identified from the 1,000,000-person cohort dataset sampled from the Taiwan National Health Insurance database. The study cohort comprised 29,688 newly diagnosed adult GERD patients; 29,597 randomly selected age-, gender-, comobidity-matched subjects comprised the comparison cohort. Cox proportional hazard regressions were performed as a means of comparing the AF-free survival rate for the two cohorts. During a maximum three years of follow-up, a total of 351 patients experienced AF, including 184 (0.62%) patients in the GERD cohort and 167 (0.56%) in the control group. The log-rank test showed that patients with GERD had significantly higher incidence of AF than those without GERD (p = 0.024). After Cox proportional hazard regression model analysis, GERD was independently associated with the increased risk of AF (hazard ratio, 1.31; 95% confidence interval, 1.06–1.61, p = 0.013). CONCLUSION: GERD was independently associated with an increased risk of future AF in a nationwide population-based cohort. Public Library of Science 2012-10-15 /pmc/articles/PMC3471851/ /pubmed/23077642 http://dx.doi.org/10.1371/journal.pone.0047575 Text en © 2012 Huang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Huang, Chin-Chou
Chan, Wan-Leong
Luo, Jiing-Chyuan
Chen, Yu-Chun
Chen, Tzeng-Ji
Chung, Chia-Min
Huang, Po-Hsun
Lin, Shing-Jong
Chen, Jaw-Wen
Leu, Hsin-Bang
Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study
title Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study
title_full Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study
title_fullStr Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study
title_full_unstemmed Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study
title_short Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study
title_sort gastroesophageal reflux disease and atrial fibrillation: a nationwide population-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471851/
https://www.ncbi.nlm.nih.gov/pubmed/23077642
http://dx.doi.org/10.1371/journal.pone.0047575
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