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High Diabetes Prevalence among Tuberculosis Cases in Kerala, India
BACKGROUND: While diabetes mellitus (DM) is a known risk factor for tuberculosis, the prevalence among TB patients in India is unknown. Routine screening of TB patients for DM may be an opportunity for its early diagnosis and improved management and might improve TB treatment outcomes. We conducted...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471898/ https://www.ncbi.nlm.nih.gov/pubmed/23077512 http://dx.doi.org/10.1371/journal.pone.0046502 |
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author | Balakrishnan, Shibu Vijayan, Shibu Nair, Sanjeev Subramoniapillai, Jayasankar Mrithyunjayan, Sunilkumar Wilson, Nevin Satyanarayana, Srinath Dewan, Puneet K. Kumar, Ajay M. V. Karthickeyan, Durai Willis, Matthew Harries, Anthony D. Nair, Sreenivas Achuthan |
author_facet | Balakrishnan, Shibu Vijayan, Shibu Nair, Sanjeev Subramoniapillai, Jayasankar Mrithyunjayan, Sunilkumar Wilson, Nevin Satyanarayana, Srinath Dewan, Puneet K. Kumar, Ajay M. V. Karthickeyan, Durai Willis, Matthew Harries, Anthony D. Nair, Sreenivas Achuthan |
author_sort | Balakrishnan, Shibu |
collection | PubMed |
description | BACKGROUND: While diabetes mellitus (DM) is a known risk factor for tuberculosis, the prevalence among TB patients in India is unknown. Routine screening of TB patients for DM may be an opportunity for its early diagnosis and improved management and might improve TB treatment outcomes. We conducted a cross-sectional survey of TB patients registered from June–July 2011 in the state of Kerala, India, to determine the prevalence of DM. METHODOLOGY/PRINCIPAL FINDINGS: A state-wide representative sample of TB patients in Kerala was interviewed and screened for DM using glycosylated hemoglobin (HbA1c); patients self-reporting a history of DM or those with HbA1c ≥6.5% were defined as diabetic. Among 552 TB patients screened, 243(44%) had DM – 128(23%) had previously known DM and 115(21%) were newly diagnosed - with higher prevalence among males and those aged >50years. The number needed to screen(NNS) to find one newly diagnosed case of DM was just four. Of 128 TB patients with previously known DM, 107(84%) had HbA1c ≥7% indicating poor glycemic control. CONCLUSIONS/SIGNIFICANCE: Nearly half of TB patients in Kerala have DM, and approximately half of these patients were newly-diagnosed during this survey. Routine screening of TB patients for DM using HbA1c yielded a large number of DM cases and offered earlier management opportunities which may improve TB and DM outcomes. However, the most cost-effective ways of DM screening need to be established by futher operational research. |
format | Online Article Text |
id | pubmed-3471898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34718982012-10-17 High Diabetes Prevalence among Tuberculosis Cases in Kerala, India Balakrishnan, Shibu Vijayan, Shibu Nair, Sanjeev Subramoniapillai, Jayasankar Mrithyunjayan, Sunilkumar Wilson, Nevin Satyanarayana, Srinath Dewan, Puneet K. Kumar, Ajay M. V. Karthickeyan, Durai Willis, Matthew Harries, Anthony D. Nair, Sreenivas Achuthan PLoS One Research Article BACKGROUND: While diabetes mellitus (DM) is a known risk factor for tuberculosis, the prevalence among TB patients in India is unknown. Routine screening of TB patients for DM may be an opportunity for its early diagnosis and improved management and might improve TB treatment outcomes. We conducted a cross-sectional survey of TB patients registered from June–July 2011 in the state of Kerala, India, to determine the prevalence of DM. METHODOLOGY/PRINCIPAL FINDINGS: A state-wide representative sample of TB patients in Kerala was interviewed and screened for DM using glycosylated hemoglobin (HbA1c); patients self-reporting a history of DM or those with HbA1c ≥6.5% were defined as diabetic. Among 552 TB patients screened, 243(44%) had DM – 128(23%) had previously known DM and 115(21%) were newly diagnosed - with higher prevalence among males and those aged >50years. The number needed to screen(NNS) to find one newly diagnosed case of DM was just four. Of 128 TB patients with previously known DM, 107(84%) had HbA1c ≥7% indicating poor glycemic control. CONCLUSIONS/SIGNIFICANCE: Nearly half of TB patients in Kerala have DM, and approximately half of these patients were newly-diagnosed during this survey. Routine screening of TB patients for DM using HbA1c yielded a large number of DM cases and offered earlier management opportunities which may improve TB and DM outcomes. However, the most cost-effective ways of DM screening need to be established by futher operational research. Public Library of Science 2012-10-15 /pmc/articles/PMC3471898/ /pubmed/23077512 http://dx.doi.org/10.1371/journal.pone.0046502 Text en © 2012 Balakrishnan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Balakrishnan, Shibu Vijayan, Shibu Nair, Sanjeev Subramoniapillai, Jayasankar Mrithyunjayan, Sunilkumar Wilson, Nevin Satyanarayana, Srinath Dewan, Puneet K. Kumar, Ajay M. V. Karthickeyan, Durai Willis, Matthew Harries, Anthony D. Nair, Sreenivas Achuthan High Diabetes Prevalence among Tuberculosis Cases in Kerala, India |
title | High Diabetes Prevalence among Tuberculosis Cases in Kerala, India |
title_full | High Diabetes Prevalence among Tuberculosis Cases in Kerala, India |
title_fullStr | High Diabetes Prevalence among Tuberculosis Cases in Kerala, India |
title_full_unstemmed | High Diabetes Prevalence among Tuberculosis Cases in Kerala, India |
title_short | High Diabetes Prevalence among Tuberculosis Cases in Kerala, India |
title_sort | high diabetes prevalence among tuberculosis cases in kerala, india |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471898/ https://www.ncbi.nlm.nih.gov/pubmed/23077512 http://dx.doi.org/10.1371/journal.pone.0046502 |
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