Cysteine 904 Is Required for Maximal Insulin Degrading Enzyme Activity and Polyanion Activation

Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme with reduced activity and decreased activation by p...

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Detalles Bibliográficos
Autores principales: Song, Eun Suk, Melikishvili, Manana, Fried, Michael G., Juliano, Maria A., Juliano, Luiz, Rodgers, David W., Hersh, Louis B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471918/
https://www.ncbi.nlm.nih.gov/pubmed/23077523
http://dx.doi.org/10.1371/journal.pone.0046790

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