Compromised Mitochondrial Fatty Acid Synthesis in Transgenic Mice Results in Defective Protein Lipoylation and Energy Disequilibrium

A mouse model with compromised mitochondrial fatty acid synthesis has been engineered in order to assess the role of this pathway in mitochondrial function and overall health. Reduction in the expression of mitochondrial malonyl CoA-acyl carrier protein transacylase, a key enzyme in the pathway enco...

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Detalles Bibliográficos
Autores principales: Smith, Stuart, Witkowski, Andrzej, Moghul, Ayesha, Yoshinaga, Yuko, Nefedov, Michael, de Jong, Pieter, Feng, Dejiang, Fong, Loren, Tu, Yiping, Hu, Yan, Young, Stephen G., Pham, Thomas, Cheung, Carling, Katzman, Shana M., Brand, Martin D., Quinlan, Casey L., Fens, Marcel, Kuypers, Frans, Misquitta, Stephanie, Griffey, Stephen M., Tran, Son, Gharib, Afshin, Knudsen, Jens, Hannibal-Bach, Hans Kristian, Wang, Grace, Larkin, Sandra, Thweatt, Jennifer, Pasta, Saloni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471957/
https://www.ncbi.nlm.nih.gov/pubmed/23077570
http://dx.doi.org/10.1371/journal.pone.0047196

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