The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

BACKGROUND: Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear. METHODS: The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P...

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Detalles Bibliográficos
Autores principales: Farfour, Eric, Charlotte, Frédéric, Settegrana, Catherine, Miyara, Makoto, Buffet, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472181/
https://www.ncbi.nlm.nih.gov/pubmed/22905863
http://dx.doi.org/10.1186/1475-2875-11-285
Descripción
Sumario:BACKGROUND: Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear. METHODS: The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria. RESULTS: A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces. DISCUSSION AND CONCLUSION: These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.

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