Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw

Recent studies have been reported that angiogenesis suppression may play a role in developing bisphosphonate-related osteonecrosis of the jaw (B-ONJ). According to these evidence we evaluated the role of VEGF as predictive marker of B-ONJ onset. Of the 81 patients, 6 developed B-ONJ following bispho...

Descripción completa

Detalles Bibliográficos
Autores principales: Vincenzi, Bruno, Napolitano, Andrea, Zoccoli, Alice, Iuliani, Michele, Pantano, Francesco, Papapietro, Nicola, Denaro, Vincenzo, Santini, Daniele, Tonini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472182/
https://www.ncbi.nlm.nih.gov/pubmed/22986334
http://dx.doi.org/10.1186/1756-8722-5-56
_version_ 1782246541736542208
author Vincenzi, Bruno
Napolitano, Andrea
Zoccoli, Alice
Iuliani, Michele
Pantano, Francesco
Papapietro, Nicola
Denaro, Vincenzo
Santini, Daniele
Tonini, Giuseppe
author_facet Vincenzi, Bruno
Napolitano, Andrea
Zoccoli, Alice
Iuliani, Michele
Pantano, Francesco
Papapietro, Nicola
Denaro, Vincenzo
Santini, Daniele
Tonini, Giuseppe
author_sort Vincenzi, Bruno
collection PubMed
description Recent studies have been reported that angiogenesis suppression may play a role in developing bisphosphonate-related osteonecrosis of the jaw (B-ONJ). According to these evidence we evaluated the role of VEGF as predictive marker of B-ONJ onset. Of the 81 patients, 6 developed B-ONJ following bisphosphonate treatment. These patients showed a strongest decrease in VEGF circulating levels at day 7 and at day 21 after the first administration. These data demonstrated for the first time that the anti-angiogenic properties of bisphosphonates are directly linked to B-ONJ pathogenesis and serum VEGF levels could represent an effective early predictive marker.
format Online
Article
Text
id pubmed-3472182
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-34721822012-10-17 Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw Vincenzi, Bruno Napolitano, Andrea Zoccoli, Alice Iuliani, Michele Pantano, Francesco Papapietro, Nicola Denaro, Vincenzo Santini, Daniele Tonini, Giuseppe J Hematol Oncol Letter to the Editor Recent studies have been reported that angiogenesis suppression may play a role in developing bisphosphonate-related osteonecrosis of the jaw (B-ONJ). According to these evidence we evaluated the role of VEGF as predictive marker of B-ONJ onset. Of the 81 patients, 6 developed B-ONJ following bisphosphonate treatment. These patients showed a strongest decrease in VEGF circulating levels at day 7 and at day 21 after the first administration. These data demonstrated for the first time that the anti-angiogenic properties of bisphosphonates are directly linked to B-ONJ pathogenesis and serum VEGF levels could represent an effective early predictive marker. BioMed Central 2012-09-17 /pmc/articles/PMC3472182/ /pubmed/22986334 http://dx.doi.org/10.1186/1756-8722-5-56 Text en Copyright ©2012 Vincenzi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Vincenzi, Bruno
Napolitano, Andrea
Zoccoli, Alice
Iuliani, Michele
Pantano, Francesco
Papapietro, Nicola
Denaro, Vincenzo
Santini, Daniele
Tonini, Giuseppe
Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw
title Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw
title_full Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw
title_fullStr Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw
title_full_unstemmed Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw
title_short Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw
title_sort serum vegf levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472182/
https://www.ncbi.nlm.nih.gov/pubmed/22986334
http://dx.doi.org/10.1186/1756-8722-5-56
work_keys_str_mv AT vincenzibruno serumvegflevelsaspredictivemarkerofbisphosphonaterelatedosteonecrosisofthejaw
AT napolitanoandrea serumvegflevelsaspredictivemarkerofbisphosphonaterelatedosteonecrosisofthejaw
AT zoccolialice serumvegflevelsaspredictivemarkerofbisphosphonaterelatedosteonecrosisofthejaw
AT iulianimichele serumvegflevelsaspredictivemarkerofbisphosphonaterelatedosteonecrosisofthejaw
AT pantanofrancesco serumvegflevelsaspredictivemarkerofbisphosphonaterelatedosteonecrosisofthejaw
AT papapietronicola serumvegflevelsaspredictivemarkerofbisphosphonaterelatedosteonecrosisofthejaw
AT denarovincenzo serumvegflevelsaspredictivemarkerofbisphosphonaterelatedosteonecrosisofthejaw
AT santinidaniele serumvegflevelsaspredictivemarkerofbisphosphonaterelatedosteonecrosisofthejaw
AT toninigiuseppe serumvegflevelsaspredictivemarkerofbisphosphonaterelatedosteonecrosisofthejaw

Ejemplares similares