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Effects of olmesartan on arterial stiffness in rats with chronic renal failure

BACKGROUND: It has been suggested that the antioxidant properties of olmesartan (OLM), an angiotensin II type 1 receptor (AT(1)R) blocker, contribute to renal protection rather than blood pressure lowering effects despite the fact that causal relationships between hypertension and renal artery disea...

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Autores principales: Chuang, Yao-Chen, Wu, Ming-Shiou, Su, Yi-Kai, Fang, Kwang-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472279/
https://www.ncbi.nlm.nih.gov/pubmed/22694778
http://dx.doi.org/10.1186/1475-2840-11-66
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author Chuang, Yao-Chen
Wu, Ming-Shiou
Su, Yi-Kai
Fang, Kwang-Ming
author_facet Chuang, Yao-Chen
Wu, Ming-Shiou
Su, Yi-Kai
Fang, Kwang-Ming
author_sort Chuang, Yao-Chen
collection PubMed
description BACKGROUND: It has been suggested that the antioxidant properties of olmesartan (OLM), an angiotensin II type 1 receptor (AT(1)R) blocker, contribute to renal protection rather than blood pressure lowering effects despite the fact that causal relationships between hypertension and renal artery disease exist. This study aimed to examine the hypothesis whether the antioxidative activities of OLM were correlated to arterial stiffness, reactive oxygen species and advanced glycation end products (AGEs) formation in rats with chronic renal failure (CRF). METHODS: CRF rats were induced by 5/6 nephrectomy and randomly assigned to an OLM (10 mg/day) group or a control group. Hemodynamic states, oxidative stress, renal function and AGEs were measured after 8 weeks of OLM treatment. RESULTS: All the hemodynamic derangements associated with renal and cardiovascular dysfunctions were abrogated in CRF rats receiving OLM. Decreased cardiac output was normalized compared to control (p <0.05). Mean aortic pressure, total peripheral resistance and left ventricular weight/body weight ratio were reduced by 21.6% (p <0.05), 28.2% (p <0.05) and 27.2% ((p <0.05). OLM also showed beneficial effects on the oscillatory components of the ventricular after-load, including 39% reduction in aortic characteristic impedance (p < 0.05), 75.3% increase in aortic compliance (p <0.05) and 50.3% increase in wave transit time (p < 0.05). These results implied that OLM attenuated the increased systolic load of the left ventricle and prevented cardiac hypertrophy in CRF rats. Improved renal function was also reflected by increases in the clearances of BUN (28.7%) and serum creatinine (SCr, 38.8%). In addition to these functional improvements, OLM specifically reduced the levels of malondialdehyde (MDA) equivalents in aorta and serum by 14.3% and 25.1%, as well as the amount of AGEs in the aortic wall by 32% (p < 0.05) of CRF rats. CONCLUSION: OLM treatment could ameliorate arterial stiffness in CRF rats with concomitant inhibition of MDA and AGEs levels through the reduction of oxidative stress in aortic wall.
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spelling pubmed-34722792012-10-23 Effects of olmesartan on arterial stiffness in rats with chronic renal failure Chuang, Yao-Chen Wu, Ming-Shiou Su, Yi-Kai Fang, Kwang-Ming Cardiovasc Diabetol Original Investigation BACKGROUND: It has been suggested that the antioxidant properties of olmesartan (OLM), an angiotensin II type 1 receptor (AT(1)R) blocker, contribute to renal protection rather than blood pressure lowering effects despite the fact that causal relationships between hypertension and renal artery disease exist. This study aimed to examine the hypothesis whether the antioxidative activities of OLM were correlated to arterial stiffness, reactive oxygen species and advanced glycation end products (AGEs) formation in rats with chronic renal failure (CRF). METHODS: CRF rats were induced by 5/6 nephrectomy and randomly assigned to an OLM (10 mg/day) group or a control group. Hemodynamic states, oxidative stress, renal function and AGEs were measured after 8 weeks of OLM treatment. RESULTS: All the hemodynamic derangements associated with renal and cardiovascular dysfunctions were abrogated in CRF rats receiving OLM. Decreased cardiac output was normalized compared to control (p <0.05). Mean aortic pressure, total peripheral resistance and left ventricular weight/body weight ratio were reduced by 21.6% (p <0.05), 28.2% (p <0.05) and 27.2% ((p <0.05). OLM also showed beneficial effects on the oscillatory components of the ventricular after-load, including 39% reduction in aortic characteristic impedance (p < 0.05), 75.3% increase in aortic compliance (p <0.05) and 50.3% increase in wave transit time (p < 0.05). These results implied that OLM attenuated the increased systolic load of the left ventricle and prevented cardiac hypertrophy in CRF rats. Improved renal function was also reflected by increases in the clearances of BUN (28.7%) and serum creatinine (SCr, 38.8%). In addition to these functional improvements, OLM specifically reduced the levels of malondialdehyde (MDA) equivalents in aorta and serum by 14.3% and 25.1%, as well as the amount of AGEs in the aortic wall by 32% (p < 0.05) of CRF rats. CONCLUSION: OLM treatment could ameliorate arterial stiffness in CRF rats with concomitant inhibition of MDA and AGEs levels through the reduction of oxidative stress in aortic wall. BioMed Central 2012-06-13 /pmc/articles/PMC3472279/ /pubmed/22694778 http://dx.doi.org/10.1186/1475-2840-11-66 Text en Copyright ©2012 Chuang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Investigation
Chuang, Yao-Chen
Wu, Ming-Shiou
Su, Yi-Kai
Fang, Kwang-Ming
Effects of olmesartan on arterial stiffness in rats with chronic renal failure
title Effects of olmesartan on arterial stiffness in rats with chronic renal failure
title_full Effects of olmesartan on arterial stiffness in rats with chronic renal failure
title_fullStr Effects of olmesartan on arterial stiffness in rats with chronic renal failure
title_full_unstemmed Effects of olmesartan on arterial stiffness in rats with chronic renal failure
title_short Effects of olmesartan on arterial stiffness in rats with chronic renal failure
title_sort effects of olmesartan on arterial stiffness in rats with chronic renal failure
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472279/
https://www.ncbi.nlm.nih.gov/pubmed/22694778
http://dx.doi.org/10.1186/1475-2840-11-66
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