Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

BACKGROUND: Dopaminergic (DA) neurons in the ventral midbrain selectively degenerate in Parkinson’s disease (PD) in part because their oxidative environment in the substantia nigra (SN) may render them vulnerable to neuroinflammatory stimuli. Chronic inhibition of soluble Tumor Necrosis Factor (TNF)...

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Detalles Bibliográficos
Autores principales: Martinez, Terina N, Chen, Xi, Bandyopadhyay, Sibali, Merrill, Alfred H, Tansey, Malú G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472284/
https://www.ncbi.nlm.nih.gov/pubmed/22973882
http://dx.doi.org/10.1186/1750-1326-7-45

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