PIWI Expression and Function in Cancer

PIWI proteins, a subclade of the Argonaute family proteins, are expressed predominantly in the germline and bind to PIWI-interacting RNAs (piRNAs), which are 25–31 nucleotides in length. The PIWI/piRNA pathway plays critical roles in germline development by regulating transposons and other targets t...

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Detalles Bibliográficos
Autores principales: Suzuki, Ryusuke, Honda, Shozo, Kirino, Yohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472457/
https://www.ncbi.nlm.nih.gov/pubmed/23087701
http://dx.doi.org/10.3389/fgene.2012.00204
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author Suzuki, Ryusuke
Honda, Shozo
Kirino, Yohei
author_facet Suzuki, Ryusuke
Honda, Shozo
Kirino, Yohei
author_sort Suzuki, Ryusuke
collection PubMed
description PIWI proteins, a subclade of the Argonaute family proteins, are expressed predominantly in the germline and bind to PIWI-interacting RNAs (piRNAs), which are 25–31 nucleotides in length. The PIWI/piRNA pathway plays critical roles in germline development by regulating transposons and other targets to maintain genome integrity. While the functions of PIWI in the germline have been extensively investigated, recent studies have accumulated evidence that the human PIWI proteins, HIWI and HILI, are aberrantly expressed in a variety of cancers. This review summarizes our knowledge of PIWI expression in cancer and discusses its possible role in tumorigenesis.
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spelling pubmed-34724572012-10-19 PIWI Expression and Function in Cancer Suzuki, Ryusuke Honda, Shozo Kirino, Yohei Front Genet Genetics PIWI proteins, a subclade of the Argonaute family proteins, are expressed predominantly in the germline and bind to PIWI-interacting RNAs (piRNAs), which are 25–31 nucleotides in length. The PIWI/piRNA pathway plays critical roles in germline development by regulating transposons and other targets to maintain genome integrity. While the functions of PIWI in the germline have been extensively investigated, recent studies have accumulated evidence that the human PIWI proteins, HIWI and HILI, are aberrantly expressed in a variety of cancers. This review summarizes our knowledge of PIWI expression in cancer and discusses its possible role in tumorigenesis. Frontiers Media S.A. 2012-10-16 /pmc/articles/PMC3472457/ /pubmed/23087701 http://dx.doi.org/10.3389/fgene.2012.00204 Text en Copyright © 2012 Suzuki, Honda and Kirino. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Genetics
Suzuki, Ryusuke
Honda, Shozo
Kirino, Yohei
PIWI Expression and Function in Cancer
title PIWI Expression and Function in Cancer
title_full PIWI Expression and Function in Cancer
title_fullStr PIWI Expression and Function in Cancer
title_full_unstemmed PIWI Expression and Function in Cancer
title_short PIWI Expression and Function in Cancer
title_sort piwi expression and function in cancer
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472457/
https://www.ncbi.nlm.nih.gov/pubmed/23087701
http://dx.doi.org/10.3389/fgene.2012.00204
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AT hondashozo piwiexpressionandfunctionincancer
AT kirinoyohei piwiexpressionandfunctionincancer

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