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Structural Basis for ASPP2 Recognition by the Tumor Suppressor p73

Tumor suppressors p53, p63 and p73 comprise a family of stress-responsive transcription factors with distinct functions in development and tumor suppression. Most human cancers lose p53 function, yet all three proteins are capable of inducing apoptosis or cellular senescence. Mechanisms are therefor...

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Detalles Bibliográficos
Autores principales: Canning, Peter, von Delft, Frank, Bullock, Alex N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472557/
https://www.ncbi.nlm.nih.gov/pubmed/22917970
http://dx.doi.org/10.1016/j.jmb.2012.08.005