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Cell Signaling through Protein Kinase C Oxidation and Activation
Due to the growing importance of cellular signaling mediated by reactive oxygen species (ROS), proteins that are reversibly modulated by these reactant molecules are of high interest. In this context, protein kinases and phosphatases, which act coordinately in the regulation of signal transduction t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472709/ https://www.ncbi.nlm.nih.gov/pubmed/23109817 http://dx.doi.org/10.3390/ijms130910697 |
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author | Cosentino-Gomes, Daniela Rocco-Machado, Nathália Meyer-Fernandes, José Roberto |
author_facet | Cosentino-Gomes, Daniela Rocco-Machado, Nathália Meyer-Fernandes, José Roberto |
author_sort | Cosentino-Gomes, Daniela |
collection | PubMed |
description | Due to the growing importance of cellular signaling mediated by reactive oxygen species (ROS), proteins that are reversibly modulated by these reactant molecules are of high interest. In this context, protein kinases and phosphatases, which act coordinately in the regulation of signal transduction through the phosphorylation and dephosphorylation of target proteins, have been described to be key elements in ROS-mediated signaling events. The major mechanism by which these proteins may be modified by oxidation involves the presence of key redox-sensitive cysteine residues. Protein kinase C (PKC) is involved in a variety of cellular signaling pathways. These proteins have been shown to contain a unique structural feature that is susceptible to oxidative modification. A large number of scientific studies have highlighted the importance of ROS as a second messenger in numerous cellular processes, including cell proliferation, gene expression, adhesion, differentiation, senescence, and apoptosis. In this context, the goal of this review is to discuss the mechanisms by which PKCs are modulated by ROS and how these processes are involved in the cellular response. |
format | Online Article Text |
id | pubmed-3472709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-34727092012-10-29 Cell Signaling through Protein Kinase C Oxidation and Activation Cosentino-Gomes, Daniela Rocco-Machado, Nathália Meyer-Fernandes, José Roberto Int J Mol Sci Review Due to the growing importance of cellular signaling mediated by reactive oxygen species (ROS), proteins that are reversibly modulated by these reactant molecules are of high interest. In this context, protein kinases and phosphatases, which act coordinately in the regulation of signal transduction through the phosphorylation and dephosphorylation of target proteins, have been described to be key elements in ROS-mediated signaling events. The major mechanism by which these proteins may be modified by oxidation involves the presence of key redox-sensitive cysteine residues. Protein kinase C (PKC) is involved in a variety of cellular signaling pathways. These proteins have been shown to contain a unique structural feature that is susceptible to oxidative modification. A large number of scientific studies have highlighted the importance of ROS as a second messenger in numerous cellular processes, including cell proliferation, gene expression, adhesion, differentiation, senescence, and apoptosis. In this context, the goal of this review is to discuss the mechanisms by which PKCs are modulated by ROS and how these processes are involved in the cellular response. Molecular Diversity Preservation International (MDPI) 2012-08-24 /pmc/articles/PMC3472709/ /pubmed/23109817 http://dx.doi.org/10.3390/ijms130910697 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Cosentino-Gomes, Daniela Rocco-Machado, Nathália Meyer-Fernandes, José Roberto Cell Signaling through Protein Kinase C Oxidation and Activation |
title | Cell Signaling through Protein Kinase C Oxidation and Activation |
title_full | Cell Signaling through Protein Kinase C Oxidation and Activation |
title_fullStr | Cell Signaling through Protein Kinase C Oxidation and Activation |
title_full_unstemmed | Cell Signaling through Protein Kinase C Oxidation and Activation |
title_short | Cell Signaling through Protein Kinase C Oxidation and Activation |
title_sort | cell signaling through protein kinase c oxidation and activation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472709/ https://www.ncbi.nlm.nih.gov/pubmed/23109817 http://dx.doi.org/10.3390/ijms130910697 |
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