New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew

Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively...

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Autores principales: Kaleem, Waqar Ahmad, Nisar, Muhammad, Qayum, Mughal, Zia-Ul-Haq, Muhammad, Adhikari, Achyut, De Feo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472760/
https://www.ncbi.nlm.nih.gov/pubmed/23109868
http://dx.doi.org/10.3390/ijms130911520
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author Kaleem, Waqar Ahmad
Nisar, Muhammad
Qayum, Mughal
Zia-Ul-Haq, Muhammad
Adhikari, Achyut
De Feo, Vincenzo
author_facet Kaleem, Waqar Ahmad
Nisar, Muhammad
Qayum, Mughal
Zia-Ul-Haq, Muhammad
Adhikari, Achyut
De Feo, Vincenzo
author_sort Kaleem, Waqar Ahmad
collection PubMed
description Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 μg/mL), Pseudomonas aeruginosa (MIC, 50 μg/mL) and Salmonella typhi (MIC, 50 μg/mL).
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spelling pubmed-34727602012-10-29 New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew Kaleem, Waqar Ahmad Nisar, Muhammad Qayum, Mughal Zia-Ul-Haq, Muhammad Adhikari, Achyut De Feo, Vincenzo Int J Mol Sci Article Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 μg/mL), Pseudomonas aeruginosa (MIC, 50 μg/mL) and Salmonella typhi (MIC, 50 μg/mL). Molecular Diversity Preservation International (MDPI) 2012-09-14 /pmc/articles/PMC3472760/ /pubmed/23109868 http://dx.doi.org/10.3390/ijms130911520 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kaleem, Waqar Ahmad
Nisar, Muhammad
Qayum, Mughal
Zia-Ul-Haq, Muhammad
Adhikari, Achyut
De Feo, Vincenzo
New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew
title New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew
title_full New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew
title_fullStr New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew
title_full_unstemmed New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew
title_short New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew
title_sort new 14-membered cyclopeptide alkaloids from zizyphus oxyphylla edgew
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472760/
https://www.ncbi.nlm.nih.gov/pubmed/23109868
http://dx.doi.org/10.3390/ijms130911520
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