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Inhibitors Incorporating Zinc-Binding Groups Target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the Causative Agent of African Sleeping Sickness
Disruption of glycosylphosphatidylinositol biosynthesis is genetically and chemically validated as a drug target against the protozoan parasite Trypanosoma brucei, the causative agent of African sleeping sickness. The N-acetylglucosamine-phosphatidylinositol de-N-acetylase (deNAc) is a zinc metalloe...
Autores principales: | Abdelwahab, Nuha Z, Crossman, Arthur T, Sullivan, Lauren, Ferguson, Michael A J, Urbaniak, Michael D |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473218/ https://www.ncbi.nlm.nih.gov/pubmed/22222041 http://dx.doi.org/10.1111/j.1747-0285.2011.01300.x |
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