Cargando…

Epidemiological Characteristics of Novel Influenza A (H1N1) in Antiviral Drug Users in Korea

Soon after the first novel influenza A (H1N1) death was documented in Korea on August 15, 2009, prompt treatment with antiviral drugs was recommended when an infection was suspected. Free antiviral drugs were distributed to patients who met the case definition in the treatment guidelines, and patien...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Kyunghi, Cho, Sung-il, Hashizume, Masahiro, Kim, Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474727/
https://www.ncbi.nlm.nih.gov/pubmed/23082184
http://dx.doi.org/10.1371/journal.pone.0047634
_version_ 1782246822091161600
author Choi, Kyunghi
Cho, Sung-il
Hashizume, Masahiro
Kim, Ho
author_facet Choi, Kyunghi
Cho, Sung-il
Hashizume, Masahiro
Kim, Ho
author_sort Choi, Kyunghi
collection PubMed
description Soon after the first novel influenza A (H1N1) death was documented in Korea on August 15, 2009, prompt treatment with antiviral drugs was recommended when an infection was suspected. Free antiviral drugs were distributed to patients who met the case definition in the treatment guidelines, and patients prescribed the antiviral drugs were included in the Antiviral Drug Surveillance System (ADSS). A total of 2,825,821 patients were reported to the ADSS from September 1 to December 31, 2009. Odds ratios were calculated to compare the risks of severe diseases, as indicated by general hospital admissions or intensive care unit (ICU) admissions according to demographic characteristics, underlying medical conditions, and behavioral factors. Approximately 6% of the total population received antiviral drugs during the study period. Of these, 2,709,611 (95.9%) were outpatients, 114,840 (4.06%) were hospitalized, and 1,370 (0.05%) were admitted to the ICU. Children aged 0–9 yr accounted for 33.94% of all reported cases, whereas only 3.89% of the patients were ≥ 60 yr. The estimated incidence of novel influenza A (H1N1) during the pandemic was 5.68/100 of all reported cases. Mortality due to influenza A (H1N1) during the pandemic was 0.33/100,000, with the highest mortality of 1.31/100,000 for patients aged ≥ 60 years. Severe pandemic H1N1 influenza was associated with the presence of one or more underlying medical conditions in elderly aged ≥ 60 years and with lower economic status. Moreover, influenza A (H1N1) appeared to be age-specific in terms of mortality. Although the incidence and admission rates of influenza A (H1N1) were higher in younger age groups, fatal cases were much more likely to occur in the elderly (≥60 years). In contrast to earlier influenza A (H1N1) reports, the risks of a severe outcome were elevated among those who were underweight (body mass index < 18.5 kg/m(2)).
format Online
Article
Text
id pubmed-3474727
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-34747272012-10-18 Epidemiological Characteristics of Novel Influenza A (H1N1) in Antiviral Drug Users in Korea Choi, Kyunghi Cho, Sung-il Hashizume, Masahiro Kim, Ho PLoS One Research Article Soon after the first novel influenza A (H1N1) death was documented in Korea on August 15, 2009, prompt treatment with antiviral drugs was recommended when an infection was suspected. Free antiviral drugs were distributed to patients who met the case definition in the treatment guidelines, and patients prescribed the antiviral drugs were included in the Antiviral Drug Surveillance System (ADSS). A total of 2,825,821 patients were reported to the ADSS from September 1 to December 31, 2009. Odds ratios were calculated to compare the risks of severe diseases, as indicated by general hospital admissions or intensive care unit (ICU) admissions according to demographic characteristics, underlying medical conditions, and behavioral factors. Approximately 6% of the total population received antiviral drugs during the study period. Of these, 2,709,611 (95.9%) were outpatients, 114,840 (4.06%) were hospitalized, and 1,370 (0.05%) were admitted to the ICU. Children aged 0–9 yr accounted for 33.94% of all reported cases, whereas only 3.89% of the patients were ≥ 60 yr. The estimated incidence of novel influenza A (H1N1) during the pandemic was 5.68/100 of all reported cases. Mortality due to influenza A (H1N1) during the pandemic was 0.33/100,000, with the highest mortality of 1.31/100,000 for patients aged ≥ 60 years. Severe pandemic H1N1 influenza was associated with the presence of one or more underlying medical conditions in elderly aged ≥ 60 years and with lower economic status. Moreover, influenza A (H1N1) appeared to be age-specific in terms of mortality. Although the incidence and admission rates of influenza A (H1N1) were higher in younger age groups, fatal cases were much more likely to occur in the elderly (≥60 years). In contrast to earlier influenza A (H1N1) reports, the risks of a severe outcome were elevated among those who were underweight (body mass index < 18.5 kg/m(2)). Public Library of Science 2012-10-17 /pmc/articles/PMC3474727/ /pubmed/23082184 http://dx.doi.org/10.1371/journal.pone.0047634 Text en © 2012 Choi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Choi, Kyunghi
Cho, Sung-il
Hashizume, Masahiro
Kim, Ho
Epidemiological Characteristics of Novel Influenza A (H1N1) in Antiviral Drug Users in Korea
title Epidemiological Characteristics of Novel Influenza A (H1N1) in Antiviral Drug Users in Korea
title_full Epidemiological Characteristics of Novel Influenza A (H1N1) in Antiviral Drug Users in Korea
title_fullStr Epidemiological Characteristics of Novel Influenza A (H1N1) in Antiviral Drug Users in Korea
title_full_unstemmed Epidemiological Characteristics of Novel Influenza A (H1N1) in Antiviral Drug Users in Korea
title_short Epidemiological Characteristics of Novel Influenza A (H1N1) in Antiviral Drug Users in Korea
title_sort epidemiological characteristics of novel influenza a (h1n1) in antiviral drug users in korea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474727/
https://www.ncbi.nlm.nih.gov/pubmed/23082184
http://dx.doi.org/10.1371/journal.pone.0047634
work_keys_str_mv AT choikyunghi epidemiologicalcharacteristicsofnovelinfluenzaah1n1inantiviraldrugusersinkorea
AT chosungil epidemiologicalcharacteristicsofnovelinfluenzaah1n1inantiviraldrugusersinkorea
AT hashizumemasahiro epidemiologicalcharacteristicsofnovelinfluenzaah1n1inantiviraldrugusersinkorea
AT kimho epidemiologicalcharacteristicsofnovelinfluenzaah1n1inantiviraldrugusersinkorea