Phosphorylation of 4E-BP1 in the Mammalian Brain Is Not Altered by LRRK2 Expression or Pathogenic Mutations

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of autosomal dominant familial Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase enzymatic domains. Disease-associated mutations in LRRK2 variably influence enzymatic activity...

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Detalles Bibliográficos
Autores principales: Trancikova, Alzbeta, Mamais, Adamantios, Webber, Philip J., Stafa, Klodjan, Tsika, Elpida, Glauser, Liliane, West, Andrew B., Bandopadhyay, Rina, Moore, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474772/
https://www.ncbi.nlm.nih.gov/pubmed/23082216
http://dx.doi.org/10.1371/journal.pone.0047784

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