Pyruvate Kinase Deficiency in Sub-Saharan Africa: Identification of a Highly Frequent Missense Mutation (G829A;Glu277Lys) and Association with Malaria

BACKGROUND: Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Saharan African countries...

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Detalles Bibliográficos
Autores principales: Machado, Patrícia, Manco, Licínio, Gomes, Cláudia, Mendes, Cristina, Fernandes, Natércia, Salomé, Graça, Sitoe, Luis, Chibute, Sérgio, Langa, José, Ribeiro, Letícia, Miranda, Juliana, Cano, Jorge, Pinto, João, Amorim, António, do Rosário, Virgílio E., Arez, Ana Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474807/
https://www.ncbi.nlm.nih.gov/pubmed/23082140
http://dx.doi.org/10.1371/journal.pone.0047071

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