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The Value of Glioma Extent of Resection in the Modern Neurosurgical Era

Objective: There remains no general consensus in the neurosurgical oncology literature regarding the role of extent of glioma resection in improving patient outcome. Although the value of resection in establishing a diagnosis and alleviating mass effect is clear, there is less certainty in ascertain...

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Detalles Bibliográficos
Autores principales: Hardesty, Douglas A., Sanai, Nader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474933/
https://www.ncbi.nlm.nih.gov/pubmed/23087667
http://dx.doi.org/10.3389/fneur.2012.00140
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author Hardesty, Douglas A.
Sanai, Nader
author_facet Hardesty, Douglas A.
Sanai, Nader
author_sort Hardesty, Douglas A.
collection PubMed
description Objective: There remains no general consensus in the neurosurgical oncology literature regarding the role of extent of glioma resection in improving patient outcome. Although the value of resection in establishing a diagnosis and alleviating mass effect is clear, there is less certainty in ascertaining the influence of extent of resection (EOR). Here, we review the recent literature to synthesize a comprehensive review of the value of extent of resection for gliomas in the modern neurosurgical era. Methods: We reviewed every major peer-reviewed clinical publication since 1990 on the role of EOR in glioma outcome. Results: Thirty-two high-grade glioma articles and 11 low-grade glioma articles were examined in terms of quality of evidence, expected EOR, and survival benefit. Conclusion: Despite limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade newly diagnosed gliomas.
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spelling pubmed-34749332012-10-19 The Value of Glioma Extent of Resection in the Modern Neurosurgical Era Hardesty, Douglas A. Sanai, Nader Front Neurol Neuroscience Objective: There remains no general consensus in the neurosurgical oncology literature regarding the role of extent of glioma resection in improving patient outcome. Although the value of resection in establishing a diagnosis and alleviating mass effect is clear, there is less certainty in ascertaining the influence of extent of resection (EOR). Here, we review the recent literature to synthesize a comprehensive review of the value of extent of resection for gliomas in the modern neurosurgical era. Methods: We reviewed every major peer-reviewed clinical publication since 1990 on the role of EOR in glioma outcome. Results: Thirty-two high-grade glioma articles and 11 low-grade glioma articles were examined in terms of quality of evidence, expected EOR, and survival benefit. Conclusion: Despite limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade newly diagnosed gliomas. Frontiers Media S.A. 2012-10-18 /pmc/articles/PMC3474933/ /pubmed/23087667 http://dx.doi.org/10.3389/fneur.2012.00140 Text en Copyright © 2012 Hardesty and Sanai. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Hardesty, Douglas A.
Sanai, Nader
The Value of Glioma Extent of Resection in the Modern Neurosurgical Era
title The Value of Glioma Extent of Resection in the Modern Neurosurgical Era
title_full The Value of Glioma Extent of Resection in the Modern Neurosurgical Era
title_fullStr The Value of Glioma Extent of Resection in the Modern Neurosurgical Era
title_full_unstemmed The Value of Glioma Extent of Resection in the Modern Neurosurgical Era
title_short The Value of Glioma Extent of Resection in the Modern Neurosurgical Era
title_sort value of glioma extent of resection in the modern neurosurgical era
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474933/
https://www.ncbi.nlm.nih.gov/pubmed/23087667
http://dx.doi.org/10.3389/fneur.2012.00140
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