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(68)Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with(18)F-FDG, calcium burden and risk factors
BACKGROUND: Ga-[1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid]-d-Phe(1),Tyr(3)-octreotate (DOTATATE) positron emission tomography (PET) is commonly used for the visualization of somatostatin receptor (SSTR)-positive neuroendocrine tumors. SSTR is also known to be expressed on macrophag...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475087/ https://www.ncbi.nlm.nih.gov/pubmed/23016793 http://dx.doi.org/10.1186/2191-219X-2-52 |
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author | Li, Xiang Samnick, Samuel Lapa, Constantin Israel, Ina Buck, Andreas K Kreissl, Michael C Bauer, Wolfgang |
author_facet | Li, Xiang Samnick, Samuel Lapa, Constantin Israel, Ina Buck, Andreas K Kreissl, Michael C Bauer, Wolfgang |
author_sort | Li, Xiang |
collection | PubMed |
description | BACKGROUND: Ga-[1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid]-d-Phe(1),Tyr(3)-octreotate (DOTATATE) positron emission tomography (PET) is commonly used for the visualization of somatostatin receptor (SSTR)-positive neuroendocrine tumors. SSTR is also known to be expressed on macrophages, which play a major role in inflammatory processes in the walls of coronary arteries and large vessels. Therefore, imaging SSTR expression has the potential to visualize vulnerable plaques. We assessed (68)Ga-DOTATATE accumulation in large vessels in comparison to (18)F-2-fluorodeoxyglucose (FDG) uptake, calcified plaques (CPs), and cardiovascular risk factors. METHODS: Sixteen consecutive patients with neuroendocrine tumors or thyroid cancer underwent both (68)Ga-DOTATATE and (18)F-FDG PET/CT for staging or restaging purposes. Detailed clinical data, including common cardiovascular risk factors, were recorded. For a separate assessment, they were divided into a high-risk and a low-risk group. In each patient, we calculated the maximum target-to-background ratio (TBR) of eight arterial segments. The correlation of the TBR(mean) of both tracers with risk factors including plaque burden was assessed. RESULTS: The mean TBR of (68)Ga-DOTATATE in all large arteries correlated significantly with the presence of CPs (r = 0.52; p < 0.05), hypertension (r = 0.60; p < 0.05), age (r = 0.56; p < 0.05), and uptake of (18)F-FDG (r = 0.64; p < 0.01). There was one significant correlation between (18)F-FDG uptake and hypertension (0.58; p < 0.05). Out of the 37 sites with the highest focal (68)Ga-DOTATATE uptake, 16 (43.2%) also had focal (18)F-FDG uptake. Of 39 sites with the highest (18)F-FDG uptake, only 11 (28.2%) had a colocalized (68)Ga-DOTATATE accumulation. CONCLUSIONS: In this series of cancer patients, we found a stronger association of increased (68)Ga-DOTATATE uptake with known risk factors of cardiovascular disease as compared to (18)F-FDG, suggesting a potential role for plaque imaging in large arteries. Strikingly, we found that focal uptake of (68)Ga-DOTATATE and (18)F-FDG does not colocalize in a significant number of lesions. |
format | Online Article Text |
id | pubmed-3475087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-34750872012-10-22 (68)Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with(18)F-FDG, calcium burden and risk factors Li, Xiang Samnick, Samuel Lapa, Constantin Israel, Ina Buck, Andreas K Kreissl, Michael C Bauer, Wolfgang EJNMMI Res Preliminary Research BACKGROUND: Ga-[1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid]-d-Phe(1),Tyr(3)-octreotate (DOTATATE) positron emission tomography (PET) is commonly used for the visualization of somatostatin receptor (SSTR)-positive neuroendocrine tumors. SSTR is also known to be expressed on macrophages, which play a major role in inflammatory processes in the walls of coronary arteries and large vessels. Therefore, imaging SSTR expression has the potential to visualize vulnerable plaques. We assessed (68)Ga-DOTATATE accumulation in large vessels in comparison to (18)F-2-fluorodeoxyglucose (FDG) uptake, calcified plaques (CPs), and cardiovascular risk factors. METHODS: Sixteen consecutive patients with neuroendocrine tumors or thyroid cancer underwent both (68)Ga-DOTATATE and (18)F-FDG PET/CT for staging or restaging purposes. Detailed clinical data, including common cardiovascular risk factors, were recorded. For a separate assessment, they were divided into a high-risk and a low-risk group. In each patient, we calculated the maximum target-to-background ratio (TBR) of eight arterial segments. The correlation of the TBR(mean) of both tracers with risk factors including plaque burden was assessed. RESULTS: The mean TBR of (68)Ga-DOTATATE in all large arteries correlated significantly with the presence of CPs (r = 0.52; p < 0.05), hypertension (r = 0.60; p < 0.05), age (r = 0.56; p < 0.05), and uptake of (18)F-FDG (r = 0.64; p < 0.01). There was one significant correlation between (18)F-FDG uptake and hypertension (0.58; p < 0.05). Out of the 37 sites with the highest focal (68)Ga-DOTATATE uptake, 16 (43.2%) also had focal (18)F-FDG uptake. Of 39 sites with the highest (18)F-FDG uptake, only 11 (28.2%) had a colocalized (68)Ga-DOTATATE accumulation. CONCLUSIONS: In this series of cancer patients, we found a stronger association of increased (68)Ga-DOTATATE uptake with known risk factors of cardiovascular disease as compared to (18)F-FDG, suggesting a potential role for plaque imaging in large arteries. Strikingly, we found that focal uptake of (68)Ga-DOTATATE and (18)F-FDG does not colocalize in a significant number of lesions. Springer 2012-09-27 /pmc/articles/PMC3475087/ /pubmed/23016793 http://dx.doi.org/10.1186/2191-219X-2-52 Text en Copyright ©2012 Li et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Preliminary Research Li, Xiang Samnick, Samuel Lapa, Constantin Israel, Ina Buck, Andreas K Kreissl, Michael C Bauer, Wolfgang (68)Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with(18)F-FDG, calcium burden and risk factors |
title | (68)Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with(18)F-FDG, calcium burden and risk factors |
title_full | (68)Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with(18)F-FDG, calcium burden and risk factors |
title_fullStr | (68)Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with(18)F-FDG, calcium burden and risk factors |
title_full_unstemmed | (68)Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with(18)F-FDG, calcium burden and risk factors |
title_short | (68)Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with(18)F-FDG, calcium burden and risk factors |
title_sort | (68)ga-dotatate pet/ct for the detection of inflammation of large arteries: correlation with(18)f-fdg, calcium burden and risk factors |
topic | Preliminary Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475087/ https://www.ncbi.nlm.nih.gov/pubmed/23016793 http://dx.doi.org/10.1186/2191-219X-2-52 |
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