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Low Zinc Status and Absorption Exist in Infants with Jejunostomies or Ileostomies Which Persists after Intestinal Repair

There is very little data regarding trace mineral nutrition in infants with small intestinal ostomies. Here we evaluated 14 infants with jejunal or ileal ostomies to measure their zinc absorption and retention and biochemical zinc and copper status. Zinc absorption was measured using a dual-tracer s...

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Autores principales: Balay, Kimberly S., Hawthorne, Keli M., Hicks, Penni D., Chen, Zhensheng, Griffin, Ian J., Abrams, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475237/
https://www.ncbi.nlm.nih.gov/pubmed/23112915
http://dx.doi.org/10.3390/nu4091273
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author Balay, Kimberly S.
Hawthorne, Keli M.
Hicks, Penni D.
Chen, Zhensheng
Griffin, Ian J.
Abrams, Steven A.
author_facet Balay, Kimberly S.
Hawthorne, Keli M.
Hicks, Penni D.
Chen, Zhensheng
Griffin, Ian J.
Abrams, Steven A.
author_sort Balay, Kimberly S.
collection PubMed
description There is very little data regarding trace mineral nutrition in infants with small intestinal ostomies. Here we evaluated 14 infants with jejunal or ileal ostomies to measure their zinc absorption and retention and biochemical zinc and copper status. Zinc absorption was measured using a dual-tracer stable isotope technique at two different time points when possible. The first study was conducted when the subject was receiving maximal tolerated feeds enterally while the ostomy remained in place. A second study was performed as soon as feasible after full feeds were achieved after intestinal repair. We found biochemical evidence of deficiencies of both zinc and copper in infants with small intestinal ostomies at both time points. Fractional zinc absorption with an ostomy in place was 10.9% ± 5.3%. After reanastamosis, fractional zinc absorption was 9.4% ± 5.7%. Net zinc balance was negative prior to reanastamosis. In conclusion, our data demonstrate that infants with a jejunostomy or ileostomy are at high risk for zinc and copper deficiency before and after intestinal reanastamosis. Additional supplementation, especially of zinc, should be considered during this time period.
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spelling pubmed-34752372012-10-30 Low Zinc Status and Absorption Exist in Infants with Jejunostomies or Ileostomies Which Persists after Intestinal Repair Balay, Kimberly S. Hawthorne, Keli M. Hicks, Penni D. Chen, Zhensheng Griffin, Ian J. Abrams, Steven A. Nutrients Article There is very little data regarding trace mineral nutrition in infants with small intestinal ostomies. Here we evaluated 14 infants with jejunal or ileal ostomies to measure their zinc absorption and retention and biochemical zinc and copper status. Zinc absorption was measured using a dual-tracer stable isotope technique at two different time points when possible. The first study was conducted when the subject was receiving maximal tolerated feeds enterally while the ostomy remained in place. A second study was performed as soon as feasible after full feeds were achieved after intestinal repair. We found biochemical evidence of deficiencies of both zinc and copper in infants with small intestinal ostomies at both time points. Fractional zinc absorption with an ostomy in place was 10.9% ± 5.3%. After reanastamosis, fractional zinc absorption was 9.4% ± 5.7%. Net zinc balance was negative prior to reanastamosis. In conclusion, our data demonstrate that infants with a jejunostomy or ileostomy are at high risk for zinc and copper deficiency before and after intestinal reanastamosis. Additional supplementation, especially of zinc, should be considered during this time period. MDPI 2012-09-12 /pmc/articles/PMC3475237/ /pubmed/23112915 http://dx.doi.org/10.3390/nu4091273 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Balay, Kimberly S.
Hawthorne, Keli M.
Hicks, Penni D.
Chen, Zhensheng
Griffin, Ian J.
Abrams, Steven A.
Low Zinc Status and Absorption Exist in Infants with Jejunostomies or Ileostomies Which Persists after Intestinal Repair
title Low Zinc Status and Absorption Exist in Infants with Jejunostomies or Ileostomies Which Persists after Intestinal Repair
title_full Low Zinc Status and Absorption Exist in Infants with Jejunostomies or Ileostomies Which Persists after Intestinal Repair
title_fullStr Low Zinc Status and Absorption Exist in Infants with Jejunostomies or Ileostomies Which Persists after Intestinal Repair
title_full_unstemmed Low Zinc Status and Absorption Exist in Infants with Jejunostomies or Ileostomies Which Persists after Intestinal Repair
title_short Low Zinc Status and Absorption Exist in Infants with Jejunostomies or Ileostomies Which Persists after Intestinal Repair
title_sort low zinc status and absorption exist in infants with jejunostomies or ileostomies which persists after intestinal repair
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475237/
https://www.ncbi.nlm.nih.gov/pubmed/23112915
http://dx.doi.org/10.3390/nu4091273
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