New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp

Five new cembrane diterpenoids, named sinuflexibilins A–E (1–5), along with nine other known diterpenoids (6–14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of th...

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Detalles Bibliográficos
Autores principales: Yang, Bin, Zhou, Xuefeng, Huang, Hui, Yang, Xian-Wen, Liu, Juan, Lin, Xiuping, Li, Xiubao, Peng, Yan, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475270/
https://www.ncbi.nlm.nih.gov/pubmed/23118718
http://dx.doi.org/10.3390/md10092023
Descripción
Sumario:Five new cembrane diterpenoids, named sinuflexibilins A–E (1–5), along with nine other known diterpenoids (6–14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay.

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