New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp

Five new cembrane diterpenoids, named sinuflexibilins A–E (1–5), along with nine other known diterpenoids (6–14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Bin, Zhou, Xuefeng, Huang, Hui, Yang, Xian-Wen, Liu, Juan, Lin, Xiuping, Li, Xiubao, Peng, Yan, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475270/
https://www.ncbi.nlm.nih.gov/pubmed/23118718
http://dx.doi.org/10.3390/md10092023
_version_ 1782246928980901888
author Yang, Bin
Zhou, Xuefeng
Huang, Hui
Yang, Xian-Wen
Liu, Juan
Lin, Xiuping
Li, Xiubao
Peng, Yan
Liu, Yonghong
author_facet Yang, Bin
Zhou, Xuefeng
Huang, Hui
Yang, Xian-Wen
Liu, Juan
Lin, Xiuping
Li, Xiubao
Peng, Yan
Liu, Yonghong
author_sort Yang, Bin
collection PubMed
description Five new cembrane diterpenoids, named sinuflexibilins A–E (1–5), along with nine other known diterpenoids (6–14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay.
format Online
Article
Text
id pubmed-3475270
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-34752702012-11-01 New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp Yang, Bin Zhou, Xuefeng Huang, Hui Yang, Xian-Wen Liu, Juan Lin, Xiuping Li, Xiubao Peng, Yan Liu, Yonghong Mar Drugs Article Five new cembrane diterpenoids, named sinuflexibilins A–E (1–5), along with nine other known diterpenoids (6–14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. MDPI 2012-09-18 /pmc/articles/PMC3475270/ /pubmed/23118718 http://dx.doi.org/10.3390/md10092023 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yang, Bin
Zhou, Xuefeng
Huang, Hui
Yang, Xian-Wen
Liu, Juan
Lin, Xiuping
Li, Xiubao
Peng, Yan
Liu, Yonghong
New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp
title New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp
title_full New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp
title_fullStr New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp
title_full_unstemmed New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp
title_short New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp
title_sort new cembrane diterpenoids from a hainan soft coral sinularia sp
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475270/
https://www.ncbi.nlm.nih.gov/pubmed/23118718
http://dx.doi.org/10.3390/md10092023
work_keys_str_mv AT yangbin newcembranediterpenoidsfromahainansoftcoralsinulariasp
AT zhouxuefeng newcembranediterpenoidsfromahainansoftcoralsinulariasp
AT huanghui newcembranediterpenoidsfromahainansoftcoralsinulariasp
AT yangxianwen newcembranediterpenoidsfromahainansoftcoralsinulariasp
AT liujuan newcembranediterpenoidsfromahainansoftcoralsinulariasp
AT linxiuping newcembranediterpenoidsfromahainansoftcoralsinulariasp
AT lixiubao newcembranediterpenoidsfromahainansoftcoralsinulariasp
AT pengyan newcembranediterpenoidsfromahainansoftcoralsinulariasp
AT liuyonghong newcembranediterpenoidsfromahainansoftcoralsinulariasp

Ejemplares similares