Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.

Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited...

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Autores principales: Lee, Yoonyeong, Jang, Kyung Hwa, Jeon, Ju-eun, Yang, Woo-Young, Sim, Chung J., Oh, Ki-Bong, Shin, Jongheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475278/
https://www.ncbi.nlm.nih.gov/pubmed/23118726
http://dx.doi.org/10.3390/md10092126
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author Lee, Yoonyeong
Jang, Kyung Hwa
Jeon, Ju-eun
Yang, Woo-Young
Sim, Chung J.
Oh, Ki-Bong
Shin, Jongheon
author_facet Lee, Yoonyeong
Jang, Kyung Hwa
Jeon, Ju-eun
Yang, Woo-Young
Sim, Chung J.
Oh, Ki-Bong
Shin, Jongheon
author_sort Lee, Yoonyeong
collection PubMed
description Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.
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spelling pubmed-34752782012-11-01 Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp. Lee, Yoonyeong Jang, Kyung Hwa Jeon, Ju-eun Yang, Woo-Young Sim, Chung J. Oh, Ki-Bong Shin, Jongheon Mar Drugs Article Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities. MDPI 2012-09-24 /pmc/articles/PMC3475278/ /pubmed/23118726 http://dx.doi.org/10.3390/md10092126 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lee, Yoonyeong
Jang, Kyung Hwa
Jeon, Ju-eun
Yang, Woo-Young
Sim, Chung J.
Oh, Ki-Bong
Shin, Jongheon
Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.
title Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.
title_full Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.
title_fullStr Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.
title_full_unstemmed Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.
title_short Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.
title_sort cyclic bis-1,3-dialkylpyridiniums from the sponge haliclona sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475278/
https://www.ncbi.nlm.nih.gov/pubmed/23118726
http://dx.doi.org/10.3390/md10092126
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