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Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD

In chronic obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), changes in bronchial microvasculature are present in response to inflammatory stimuli. Vascular changes may significantly contribute to airway wall remodelling. Angiogenesis and vascular leakage...

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Detalles Bibliográficos
Autores principales: Chetta, Alfredo, Olivieri, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475307/
https://www.ncbi.nlm.nih.gov/pubmed/23093959
http://dx.doi.org/10.1155/2012/397693
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author Chetta, Alfredo
Olivieri, Dario
author_facet Chetta, Alfredo
Olivieri, Dario
author_sort Chetta, Alfredo
collection PubMed
description In chronic obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), changes in bronchial microvasculature are present in response to inflammatory stimuli. Vascular changes may significantly contribute to airway wall remodelling. Angiogenesis and vascular leakage are prevalent in asthma, while vasodilation and vascular leakage dominate in COPD. An endothelial dysfunction may be present both in asthma and in COPD. Vascular changes may occur simultaneously with the thickening of the airway wall and the narrowing of the bronchial lumen. Consequently, pharmacological control of bronchial vascular remodelling may be crucial for symptom control in asthma and COPD. In asthmatic airways, inhaled steroids can downregulate vascular remodelling by acting on proangiogenic factors. Additionally, studies on combination therapy with long-acting β2-agonists and inhaled steroids have provided evidence of a possible synergistic action on components of vascular remodelling in asthma. In COPD, there is less experimental evidence on the effect of inhaled steroids on airway microvascular changes. Importantly, vascular endothelial growth factor (VEGF), the most specific growth factor for vascular endothelium, is crucially involved in the pathophysiology of airway vascular remodelling, both in asthma and COPD. The inhibition of VEGF and its receptor may be useful in the treatment of the vascular changes in the airway wall.
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spelling pubmed-34753072012-10-23 Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD Chetta, Alfredo Olivieri, Dario Int J Endocrinol Review Article In chronic obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), changes in bronchial microvasculature are present in response to inflammatory stimuli. Vascular changes may significantly contribute to airway wall remodelling. Angiogenesis and vascular leakage are prevalent in asthma, while vasodilation and vascular leakage dominate in COPD. An endothelial dysfunction may be present both in asthma and in COPD. Vascular changes may occur simultaneously with the thickening of the airway wall and the narrowing of the bronchial lumen. Consequently, pharmacological control of bronchial vascular remodelling may be crucial for symptom control in asthma and COPD. In asthmatic airways, inhaled steroids can downregulate vascular remodelling by acting on proangiogenic factors. Additionally, studies on combination therapy with long-acting β2-agonists and inhaled steroids have provided evidence of a possible synergistic action on components of vascular remodelling in asthma. In COPD, there is less experimental evidence on the effect of inhaled steroids on airway microvascular changes. Importantly, vascular endothelial growth factor (VEGF), the most specific growth factor for vascular endothelium, is crucially involved in the pathophysiology of airway vascular remodelling, both in asthma and COPD. The inhibition of VEGF and its receptor may be useful in the treatment of the vascular changes in the airway wall. Hindawi Publishing Corporation 2012 2012-10-11 /pmc/articles/PMC3475307/ /pubmed/23093959 http://dx.doi.org/10.1155/2012/397693 Text en Copyright © 2012 A. Chetta and D. Olivieri. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chetta, Alfredo
Olivieri, Dario
Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD
title Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD
title_full Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD
title_fullStr Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD
title_full_unstemmed Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD
title_short Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD
title_sort role of inhaled steroids in vascular airway remodelling in asthma and copd
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475307/
https://www.ncbi.nlm.nih.gov/pubmed/23093959
http://dx.doi.org/10.1155/2012/397693
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