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Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan
Endemic areas of human T-lymphotropic virus type 1 (HTLV-1) have been reported in Japan as well as tropical Africa, Central and South America and Melanesia. The existence of two subgroups, i.e., the transcontinental and Japanese subgroups, was reported in Japan. In the present study, we provide data...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society of Tropical Medicine
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475314/ https://www.ncbi.nlm.nih.gov/pubmed/23097620 http://dx.doi.org/10.2149/tmh.2012-02 |
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author | Otani, Masashi Honda, Noritaka Xia, Pin-Cang Eguchi, Katsuyuki Ichikawa, Tatsuki Watanabe, Toshiki Yamaguchi, Kazunari Nakao, Kazuhiko Yamamoto, Taro |
author_facet | Otani, Masashi Honda, Noritaka Xia, Pin-Cang Eguchi, Katsuyuki Ichikawa, Tatsuki Watanabe, Toshiki Yamaguchi, Kazunari Nakao, Kazuhiko Yamamoto, Taro |
author_sort | Otani, Masashi |
collection | PubMed |
description | Endemic areas of human T-lymphotropic virus type 1 (HTLV-1) have been reported in Japan as well as tropical Africa, Central and South America and Melanesia. The existence of two subgroups, i.e., the transcontinental and Japanese subgroups, was reported in Japan. In the present study, we provide data on the ratio of the two subgroups in each endemic area and infection foci and examine the distribution of HTLV-1 in Japan and neighboring areas. A 657 bp fragment of env region of HTLV-1 proviral genome was successfully amplified for 183 HTLV-1 positive DNA samples. The subgroup determination was done by RFLP reactions using endonucleases HpaI and HinfI. The northern part of mainland Kyushu, represented by Hirado and Kumamoto, was monopolized by the Japanese subgroup, while the transcontinental subgroup ranged from 20 to 35% in the Pacific coast areas of Shikoku (Kochi), the Ryukyu Archipelago (Kakeroma and Okinawa) and Taiwan. An interesting finding in the present study is the presence of the transcontinental subgroup in Kochi, suggesting the endemicity of the transcontinental subgroup along the Kuroshio Current. |
format | Online Article Text |
id | pubmed-3475314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Japanese Society of Tropical Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-34753142012-10-24 Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan Otani, Masashi Honda, Noritaka Xia, Pin-Cang Eguchi, Katsuyuki Ichikawa, Tatsuki Watanabe, Toshiki Yamaguchi, Kazunari Nakao, Kazuhiko Yamamoto, Taro Trop Med Health Original Article Endemic areas of human T-lymphotropic virus type 1 (HTLV-1) have been reported in Japan as well as tropical Africa, Central and South America and Melanesia. The existence of two subgroups, i.e., the transcontinental and Japanese subgroups, was reported in Japan. In the present study, we provide data on the ratio of the two subgroups in each endemic area and infection foci and examine the distribution of HTLV-1 in Japan and neighboring areas. A 657 bp fragment of env region of HTLV-1 proviral genome was successfully amplified for 183 HTLV-1 positive DNA samples. The subgroup determination was done by RFLP reactions using endonucleases HpaI and HinfI. The northern part of mainland Kyushu, represented by Hirado and Kumamoto, was monopolized by the Japanese subgroup, while the transcontinental subgroup ranged from 20 to 35% in the Pacific coast areas of Shikoku (Kochi), the Ryukyu Archipelago (Kakeroma and Okinawa) and Taiwan. An interesting finding in the present study is the presence of the transcontinental subgroup in Kochi, suggesting the endemicity of the transcontinental subgroup along the Kuroshio Current. The Japanese Society of Tropical Medicine 2012-06 2012-08-04 /pmc/articles/PMC3475314/ /pubmed/23097620 http://dx.doi.org/10.2149/tmh.2012-02 Text en © 2012 Japanese Society of Tropical Medicine This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Otani, Masashi Honda, Noritaka Xia, Pin-Cang Eguchi, Katsuyuki Ichikawa, Tatsuki Watanabe, Toshiki Yamaguchi, Kazunari Nakao, Kazuhiko Yamamoto, Taro Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan |
title | Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan |
title_full | Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan |
title_fullStr | Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan |
title_full_unstemmed | Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan |
title_short | Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan |
title_sort | distribution of two subgroups of human t-lymphotropic virus type 1 (htlv-1) in endemic japan |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475314/ https://www.ncbi.nlm.nih.gov/pubmed/23097620 http://dx.doi.org/10.2149/tmh.2012-02 |
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