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Bioactivation of Nevirapine to a Reactive Quinone Methide: Implications for Liver Injury
[Image: see text] Nevirapine (NVP) treatment is associated with a significant incidence of liver injury. We developed an anti-NVP antiserum to determine the presence and pattern of covalent binding of NVP to mouse, rat, and human hepatic tissues. Covalent binding to hepatic microsomes from male C57B...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475366/ https://www.ncbi.nlm.nih.gov/pubmed/22793666 http://dx.doi.org/10.1021/tx300172s |