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Bioactivation of Nevirapine to a Reactive Quinone Methide: Implications for Liver Injury

[Image: see text] Nevirapine (NVP) treatment is associated with a significant incidence of liver injury. We developed an anti-NVP antiserum to determine the presence and pattern of covalent binding of NVP to mouse, rat, and human hepatic tissues. Covalent binding to hepatic microsomes from male C57B...

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Detalles Bibliográficos
Autores principales: Sharma, Amy M., Li, Yan, Novalen, Maria, Hayes, M. Anthony, Uetrecht, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475366/
https://www.ncbi.nlm.nih.gov/pubmed/22793666
http://dx.doi.org/10.1021/tx300172s

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