A novel dual-fluorescence strategy for functionally validating microRNA targets in 3′ untranslated regions: regulation of the inward rectifier potassium channel K(ir)2.1 by miR-212

Gene targeting by microRNAs is important in health and disease. We developed a functional assay for identifying microRNA targets and applied it to the K(+) channel K(ir)2.1 [KCNJ2 (potassium inwardly-rectifying channel, subfamily J, member 2)] which is dysregulated in cardiac and vascular disorders....

Descripción completa

Detalles Bibliográficos
Autores principales: Goldoni, Dana, Yarham, Janet M., McGahon, Mary K., O’Connor, Anna, Guduric-Fuchs, Jasenka, Edgar, Kevin, McDonald, Denise M., Simpson, David A., Collins, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475433/
https://www.ncbi.nlm.nih.gov/pubmed/22880819
http://dx.doi.org/10.1042/BJ20120578

Ejemplares similares

Ejemplares similares