Selective silencing of DNA topoisomerase IIβ in human mesenchymal stem cells by siRNAs (small interfering RNAs)

hMSCs (human mesenchymal stem cells) express two isoforms of DNA topo II (topoisomerase II). Although both isoforms have the same catalytic activity, they are specialized for different functions in the cell: while topo IIα is essential for chromosome segregation in mitotic cells, topo IIβ is involve...

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Detalles Bibliográficos
Autores principales: Kamaci, Nebiyyeh, Emnacar, Tuba, Karakas, Nihal, Arikan, Gulsum, Tsutsui, Ken, Isik, Sevim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475440/
https://www.ncbi.nlm.nih.gov/pubmed/23119146
http://dx.doi.org/10.1042/CBR20110003

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