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pncA Mutations in the Specimens from Extrapulmonary Tuberculosis

BACKGROUND: Pyrazinamide (PZA) is an effective antitubercular drug that becomes toxic to Mycobacterium tuberculosis when converted to pyrazinoic acid by pyrazinamidase (PZase), encoded by mycobacterial pncA. A strong association was noted between the loss of PZase activity and PZA resistance. The ca...

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Detalles Bibliográficos
Autores principales:	Lee, Jaechun, Yun, Yeo-Jun, Kqueen, Cheah Yoke, Lee, Jong Hoo, Kim, Hee-Youn, Kim, Young Ree, Kook, Yoon-Hoh, Lee, Keun Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Academy of Tuberculosis and Respiratory Diseases 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475457/ https://www.ncbi.nlm.nih.gov/pubmed/23101013 http://dx.doi.org/10.4046/trd.2012.72.6.475

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