An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

Phosphorylation is an abundant post-translational modification involved in a myriad of cell signaling pathways. Herein, we have engineered the class II lantipeptide synthetase ProcM to generate a variety of peptides containing O-phosphoserine (pSer) and O-phosphothreonine (pThr) residues, either in...

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Detalles Bibliográficos
Autores principales: Thibodeaux, Gabrielle N., van der Donk, Wilfred A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2012
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475617/
https://www.ncbi.nlm.nih.gov/pubmed/23001385
http://dx.doi.org/10.1039/c2cc34138g
Descripción
Sumario:Phosphorylation is an abundant post-translational modification involved in a myriad of cell signaling pathways. Herein, we have engineered the class II lantipeptide synthetase ProcM to generate a variety of peptides containing O-phosphoserine (pSer) and O-phosphothreonine (pThr) residues, either in vitro or in vivo.

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