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An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase
Phosphorylation is an abundant post-translational modification involved in a myriad of cell signaling pathways. Herein, we have engineered the class II lantipeptide synthetase ProcM to generate a variety of peptides containing O-phosphoserine (pSer) and O-phosphothreonine (pThr) residues, either in...
Autores principales: | Thibodeaux, Gabrielle N., van der Donk, Wilfred A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475617/ https://www.ncbi.nlm.nih.gov/pubmed/23001385 http://dx.doi.org/10.1039/c2cc34138g |
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