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A Structural Systems Biology Approach for Quantifying the Systemic Consequences of Missense Mutations in Proteins

Gauging the systemic effects of non-synonymous single nucleotide polymorphisms (nsSNPs) is an important topic in the pursuit of personalized medicine. However, it is a non-trivial task to understand how a change at the protein structure level eventually affects a cell's behavior. This is becaus...

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Detalles Bibliográficos
Autores principales:	Cheng, Tammy M. K., Goehring, Lucas, Jeffery, Linda, Lu, Yu-En, Hayles, Jacqueline, Novák, Béla, Bates, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475653/ https://www.ncbi.nlm.nih.gov/pubmed/23093928 http://dx.doi.org/10.1371/journal.pcbi.1002738

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