Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila

Gastric cancer development is strongly correlated with infection by Helicobacter pylori possessing the effector protein CagA. Using a transgenic Drosophila melanogaster model, we show that CagA expression in the simple model epithelium of the larval wing imaginal disc causes dramatic tissue perturba...

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Detalles Bibliográficos
Autores principales: Wandler, Anica M., Guillemin, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475654/
https://www.ncbi.nlm.nih.gov/pubmed/23093933
http://dx.doi.org/10.1371/journal.ppat.1002939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475654/
https://www.ncbi.nlm.nih.gov/pubmed/23093933
http://dx.doi.org/10.1371/journal.ppat.1002939

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