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Stabilization of metastatic myxopapillary ependymoma with sorafenib
We report on a 59-year old woman with three huge intrathoracal masses that were accidentally diagnosed when she consulted a physician for upper abdominal discomfort. A biopsy revealed that they were metastases of a coccygeal myxopapillary ependymoma, resected 20 years before. As neither resection, d...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475949/ https://www.ncbi.nlm.nih.gov/pubmed/23087798 http://dx.doi.org/10.4081/rt.2012.e42 |
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author | Fegerl, Gundula Marosi, Christine |
author_facet | Fegerl, Gundula Marosi, Christine |
author_sort | Fegerl, Gundula |
collection | PubMed |
description | We report on a 59-year old woman with three huge intrathoracal masses that were accidentally diagnosed when she consulted a physician for upper abdominal discomfort. A biopsy revealed that they were metastases of a coccygeal myxopapillary ependymoma, resected 20 years before. As neither resection, debulking, nor radiation therapy were considered to be indicated, systemic therapy with temozolomide was started. At the first evaluation after four months, the metastases had progressed. Imatinib delayed the progression, but had to be stopped after six months because of critical increased pleural effusion. Using the multikinase inhibitor sorafenib, the disease was stabilized and an acceptable quality of life could be obtained for one year. |
format | Online Article Text |
id | pubmed-3475949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | PAGEPress Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-34759492012-10-19 Stabilization of metastatic myxopapillary ependymoma with sorafenib Fegerl, Gundula Marosi, Christine Rare Tumors Case Report We report on a 59-year old woman with three huge intrathoracal masses that were accidentally diagnosed when she consulted a physician for upper abdominal discomfort. A biopsy revealed that they were metastases of a coccygeal myxopapillary ependymoma, resected 20 years before. As neither resection, debulking, nor radiation therapy were considered to be indicated, systemic therapy with temozolomide was started. At the first evaluation after four months, the metastases had progressed. Imatinib delayed the progression, but had to be stopped after six months because of critical increased pleural effusion. Using the multikinase inhibitor sorafenib, the disease was stabilized and an acceptable quality of life could be obtained for one year. PAGEPress Publications 2012-09-06 /pmc/articles/PMC3475949/ /pubmed/23087798 http://dx.doi.org/10.4081/rt.2012.e42 Text en ©Copyright G. Fegerl and C. Marosi, 2012 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy |
spellingShingle | Case Report Fegerl, Gundula Marosi, Christine Stabilization of metastatic myxopapillary ependymoma with sorafenib |
title | Stabilization of metastatic myxopapillary ependymoma with sorafenib |
title_full | Stabilization of metastatic myxopapillary ependymoma with sorafenib |
title_fullStr | Stabilization of metastatic myxopapillary ependymoma with sorafenib |
title_full_unstemmed | Stabilization of metastatic myxopapillary ependymoma with sorafenib |
title_short | Stabilization of metastatic myxopapillary ependymoma with sorafenib |
title_sort | stabilization of metastatic myxopapillary ependymoma with sorafenib |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475949/ https://www.ncbi.nlm.nih.gov/pubmed/23087798 http://dx.doi.org/10.4081/rt.2012.e42 |
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