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Arg9 facilitates the translocation and downstream signal inhibition of an anti-HER2 single chain antibody

BACKGROUND: HER2 plays a critical role in the pathogenesis of many cancers and is linked to poor prognosis or cancer metastases. Monoclonal antibodies, such as Herceptin against HER2-overexpressing cancers, have showed satisfactory clinical therapeutic effect. However, they have difficulty to surmou...

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Detalles Bibliográficos
Autores principales:	Hu, Yi, Qiao, Chunxia, Lv, Ming, Feng, Jiannan, Yu, Ming, Shen, Beifen, Zhang, Qiuping, Li, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477046/ https://www.ncbi.nlm.nih.gov/pubmed/22748113 http://dx.doi.org/10.1186/1756-0500-5-336

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