Cargando…

Arg9 facilitates the translocation and downstream signal inhibition of an anti-HER2 single chain antibody

BACKGROUND: HER2 plays a critical role in the pathogenesis of many cancers and is linked to poor prognosis or cancer metastases. Monoclonal antibodies, such as Herceptin against HER2-overexpressing cancers, have showed satisfactory clinical therapeutic effect. However, they have difficulty to surmou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Yi, Qiao, Chunxia, Lv, Ming, Feng, Jiannan, Yu, Ming, Shen, Beifen, Zhang, Qiuping, Li, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477046/ https://www.ncbi.nlm.nih.gov/pubmed/22748113 http://dx.doi.org/10.1186/1756-0500-5-336

Ejemplares similares

Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3
por: Wang, Wei, et al.
Publicado: (2014)

Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation
por: Qiao, Chunxia, et al.
Publicado: (2012)

Structural and functional characterization of MBS301, an afucosylated bispecific anti-HER2 antibody
por: Huang, Sijia, et al.
Publicado: (2018)

Pharmacological characteristics and efficacy of a novel anti-angiogenic antibody FD006 in corneal neovascularization
por: Wang, Qun, et al.
Publicado: (2014)

A Novel Humanized Anti-Abrin A Chain Antibody Inhibits Abrin Toxicity In Vitro and In Vivo
por: Peng, Jingyi, et al.
Publicado: (2022)

Functional epitopes and neutralizing antibodies of vaccinia virus
por: Peng, Fenghao, et al.
Publicado: (2023)

Novel anti-CD38 humanized mAb SG003 possessed enhanced cytotoxicity in lymphoma than Daratumumab via antibody-dependent cell-mediated cytotoxicity
por: Yu, Tao, et al.
Publicado: (2019)

Identification of a Human Anti-Alpha-Toxin Monoclonal Antibody Against Staphylococcus aureus Infection
por: Liu, Fangjie, et al.
Publicado: (2021)

Therapeutic potential of an anti-HER2 single chain antibody–DM1 conjugates for the treatment of HER2-positive cancer
por: Zhang, Hang, et al.
Publicado: (2017)

Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab
por: Vazquez-Martin, Alejandro, et al.
Publicado: (2009)

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database
por: Wang, Jing, et al.
Publicado: (2016)

Anti-Axl monoclonal antibodies attenuate the migration of MDA-MB-231 breast cancer cells
por: Chang, Hong, et al.
Publicado: (2021)

Fusion of apoptosis‐related protein Cytochrome c with anti‐HER‐2 single‐chain antibody targets the suppression of HER‐2+ breast cancer
por: Lu, DanDan, et al.
Publicado: (2021)

Resistance to anti-HER2 therapy associated with the TSC2 nonsynonymous variant c.4349 C > G (p.Pro1450Arg) is reversed by CDK4/6 inhibitor in HER2-positive breast cancer
por: Yang, Ziyan, et al.
Publicado: (2023)

HER2 heterogeneity and resistance to anti-HER2 antibody-drug conjugates
por: Ocaña, Alberto, et al.
Publicado: (2020)

MAE4, an eLtaS monoclonal antibody, blocks Staphylococcus aureus virulence
por: Liu, Yu, et al.
Publicado: (2015)

Membrane translocation of lumenal domains of membrane proteins powered by downstream transmembrane sequences
por: Yabuki, Takaaki, et al.
Publicado: (2013)

Translocation kinetics and structural dynamics of ribosomes are modulated by the conformational plasticity of downstream pseudoknots
por: Wu, Bo, et al.
Publicado: (2018)

Structure-guided affinity maturation of a novel human antibody targeting the SARS-CoV-2 nucleocapsid protein
por: Wang, Zhihong, et al.
Publicado: (2022)

Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene
por: Yang, Ming-Hui, et al.
Publicado: (2019)

Enhancement of Campylobacter hepaticus culturing to facilitate downstream applications
por: Phung, Canh, et al.
Publicado: (2021)

Both p53 codon 72 Arg/Arg and pro/Arg genotypes in glioblastoma multiforme are associated with a better prognosis in bevacizumab treatment
por: Shen, Chiung-Chyi, et al.
Publicado: (2020)

HER3 targeting with an antibody‐drug conjugate bypasses resistance to anti‐HER2 therapies
por: Gandullo‐Sánchez, Lucía, et al.
Publicado: (2020)

Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer
por: Schneeweiss, Andreas, et al.
Publicado: (2018)

Downstream promoter interactions of TFIID TAFs facilitate transcription reinitiation
por: Joo, Yoo Jin, et al.
Publicado: (2017)

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
por: Da Silva, Leonard, et al.
Publicado: (2010)

Heavier Lies Her Crown: Gendered Patterns of Leader Emotional Labor and Their Downstream Effects
por: Vial, Andrea C., et al.
Publicado: (2022)

GM-CSF facilitates the development of inflammation-associated colorectal carcinoma
por: Chen, Guojiang, et al.
Publicado: (2014)

An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity
por: Weisser, Nina E., et al.
Publicado: (2023)

A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis
por: Gupta, Pooja, et al.
Publicado: (2021)

Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis
por: Wang, Jing, et al.
Publicado: (2011)

Bispecific antibodies (anti-mPEG/anti-HER2) for active tumor targeting of docetaxel (DTX)-loaded mPEGylated nanocarriers to enhance the chemotherapeutic efficacy of HER2-overexpressing tumors
por: Su, Chia-Yu, et al.
Publicado: (2018)

Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response
por: Chen, Zhao, et al.
Publicado: (2023)

Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly
por: Farràs, Mercè, et al.
Publicado: (2019)

β2‐AR activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells
por: Liu, Dan, et al.
Publicado: (2020)

Vaccinia Virus Inhibits NF-κB-Dependent Gene Expression Downstream of p65 Translocation
por: Sumner, Rebecca P., et al.
Publicado: (2014)

Gene therapy using plasmid DNA-encoded anti-HER2 antibody for cancers that overexpress HER2
por: Kim, H, et al.
Publicado: (2016)

Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody
por: Cheng, Jackie, et al.
Publicado: (2020)

Conformational characterization of a novel anti-HER2 candidate antibody
por: Moro Pérez, Leina, et al.
Publicado: (2019)

Current trends and challenges in the downstream purification of bispecific antibodies
por: Chen, Serene W, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hr9vliih5o0u92t54f9avep5nu