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Benefits of using magnesium sulphate (MgSO(4)) for eclampsia management and maternal mortality reduction: lessons from Kano State in Northern Nigeria
BACKGROUND: Despite clear emphasis through the Millennium Development Goals, the problem of high maternal mortality persists especially within low and middle income countries. Various studies report remarkably high maternal mortality rates in northern Nigeria, where maternal mortality rates exceed 1...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477064/ https://www.ncbi.nlm.nih.gov/pubmed/22873658 http://dx.doi.org/10.1186/1756-0500-5-421 |
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author | Okereke, Ekechi Ahonsi, Babatunde Tukur, Jamilu Ishaku, Salisu Mohammed Oginni, Ayodeji Babatunde |
author_facet | Okereke, Ekechi Ahonsi, Babatunde Tukur, Jamilu Ishaku, Salisu Mohammed Oginni, Ayodeji Babatunde |
author_sort | Okereke, Ekechi |
collection | PubMed |
description | BACKGROUND: Despite clear emphasis through the Millennium Development Goals, the problem of high maternal mortality persists especially within low and middle income countries. Various studies report remarkably high maternal mortality rates in northern Nigeria, where maternal mortality rates exceed 1,000 deaths per 100,000 live births and eclampsia contributes approximately 40% of maternal deaths. Across Nigeria, diazepam is routinely used for the management of eclampsia. Prior to February 2008, diazepam was widely used for the management of eclampsia in Kano State (within northern Nigeria) with case fatality rate being over 20%. While magnesium sulphate (MgSO(4)) is recognized as the most effective drug for the management of eclampsia; this study aims to compare MgSO(4) therapy with diazepam therapy in terms of case fatality rates and costs. FINDINGS: This retrospective study, including 1045 patients with eclampsia and pre-eclampsia during the years 2008 and 2009, reports a drop in case fatality rates from 20.9% (95% CI: 18.7, 23.2) to 2.3% (95% CI: 1.4, 3.2) among eclampsia patients following the MgSO(4) intervention. The study observed no significant difference in the cost of using MgSO(4) therapy compared to diazepam therapy. CONCLUSIONS: The study found a remarkable reduction in case fatality rate due to eclampsia in those who received MgSO(4) therapy with minimal increase in costs when compared to diazepam therapy. Concerted efforts should be focused on properly introducing MgSO(4) into emergency obstetric protocols especially within developing countries to reduce maternal mortality and also impact on health system performance. |
format | Online Article Text |
id | pubmed-3477064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34770642012-10-20 Benefits of using magnesium sulphate (MgSO(4)) for eclampsia management and maternal mortality reduction: lessons from Kano State in Northern Nigeria Okereke, Ekechi Ahonsi, Babatunde Tukur, Jamilu Ishaku, Salisu Mohammed Oginni, Ayodeji Babatunde BMC Res Notes Short Report BACKGROUND: Despite clear emphasis through the Millennium Development Goals, the problem of high maternal mortality persists especially within low and middle income countries. Various studies report remarkably high maternal mortality rates in northern Nigeria, where maternal mortality rates exceed 1,000 deaths per 100,000 live births and eclampsia contributes approximately 40% of maternal deaths. Across Nigeria, diazepam is routinely used for the management of eclampsia. Prior to February 2008, diazepam was widely used for the management of eclampsia in Kano State (within northern Nigeria) with case fatality rate being over 20%. While magnesium sulphate (MgSO(4)) is recognized as the most effective drug for the management of eclampsia; this study aims to compare MgSO(4) therapy with diazepam therapy in terms of case fatality rates and costs. FINDINGS: This retrospective study, including 1045 patients with eclampsia and pre-eclampsia during the years 2008 and 2009, reports a drop in case fatality rates from 20.9% (95% CI: 18.7, 23.2) to 2.3% (95% CI: 1.4, 3.2) among eclampsia patients following the MgSO(4) intervention. The study observed no significant difference in the cost of using MgSO(4) therapy compared to diazepam therapy. CONCLUSIONS: The study found a remarkable reduction in case fatality rate due to eclampsia in those who received MgSO(4) therapy with minimal increase in costs when compared to diazepam therapy. Concerted efforts should be focused on properly introducing MgSO(4) into emergency obstetric protocols especially within developing countries to reduce maternal mortality and also impact on health system performance. BioMed Central 2012-08-08 /pmc/articles/PMC3477064/ /pubmed/22873658 http://dx.doi.org/10.1186/1756-0500-5-421 Text en Copyright ©2012 Okereke et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Okereke, Ekechi Ahonsi, Babatunde Tukur, Jamilu Ishaku, Salisu Mohammed Oginni, Ayodeji Babatunde Benefits of using magnesium sulphate (MgSO(4)) for eclampsia management and maternal mortality reduction: lessons from Kano State in Northern Nigeria |
title | Benefits of using magnesium sulphate (MgSO(4)) for eclampsia management and maternal mortality reduction: lessons from Kano State in Northern Nigeria |
title_full | Benefits of using magnesium sulphate (MgSO(4)) for eclampsia management and maternal mortality reduction: lessons from Kano State in Northern Nigeria |
title_fullStr | Benefits of using magnesium sulphate (MgSO(4)) for eclampsia management and maternal mortality reduction: lessons from Kano State in Northern Nigeria |
title_full_unstemmed | Benefits of using magnesium sulphate (MgSO(4)) for eclampsia management and maternal mortality reduction: lessons from Kano State in Northern Nigeria |
title_short | Benefits of using magnesium sulphate (MgSO(4)) for eclampsia management and maternal mortality reduction: lessons from Kano State in Northern Nigeria |
title_sort | benefits of using magnesium sulphate (mgso(4)) for eclampsia management and maternal mortality reduction: lessons from kano state in northern nigeria |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477064/ https://www.ncbi.nlm.nih.gov/pubmed/22873658 http://dx.doi.org/10.1186/1756-0500-5-421 |
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