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Phenolic-glycolipid-1 and lipoarabinomannan preferentially modulate TCR- and CD28-triggered proximal biochemical events, leading to T-cell unresponsiveness in mycobacterial diseases

BACKGROUND: Advanced stages of leprosy show T cell unresponsiveness and lipids of mycobacterial origin are speculated to modulate immune responses in these patients. Present study elucidates the role of phenolicglycolipid (PGL-1) and Mannose-capped lipoarabinomannan (Man-LAM) on TCR- and TCR/CD28- m...

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Detalles Bibliográficos
Autores principales:	Dagur, Pradeep Kumar, Sharma, Bhawna, Upadhyay, Rajni, Dua, Bhavyata, Rizvi, Arshad, Khan, Naim Akhtar, Katoch, Vishwa Mohan, Sengupta, Utpal, Joshi, Beenu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477116/ https://www.ncbi.nlm.nih.gov/pubmed/22985026 http://dx.doi.org/10.1186/1476-511X-11-119

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