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The Free Energy Barrier for Arginine Gating Charge Translation Is Altered by Mutations in the Voltage Sensor Domain

The gating of voltage-gated ion channels is controlled by the arginine-rich S4 helix of the voltage-sensor domain moving in response to an external potential. Recent studies have suggested that S4 moves in three to four steps to open the conducting pore, thus visiting several intermediate conformati...

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Detalles Bibliográficos
Autores principales:	Schwaiger, Christine S., Börjesson, Sara I., Hess, Berk, Wallner, Björn, Elinder, Fredrik, Lindahl, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477161/ https://www.ncbi.nlm.nih.gov/pubmed/23094020 http://dx.doi.org/10.1371/journal.pone.0045880

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