Improved eIF4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects

Eukaryotic initiation factor (eIF)4E is over-expressed in many types of cancer such as breast, head and neck, and lung. A consequence of increased levels of eIF4E is the preferential translation of pro-tumorigenic proteins (e.g. c-Myc and vascular endothelial growth factor) and as a result is regard...

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Detalles Bibliográficos
Autores principales: Zhou, Weizhuang, Quah, Soo T., Verma, Chandra S., Liu, Yun, Lane, David P., Brown, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477164/
https://www.ncbi.nlm.nih.gov/pubmed/23094039
http://dx.doi.org/10.1371/journal.pone.0047235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477164/
https://www.ncbi.nlm.nih.gov/pubmed/23094039
http://dx.doi.org/10.1371/journal.pone.0047235

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