Evolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases

The extent to which evolutionary changes have impacted the phenotypic relationships among human diseases remains unclear. In this work, we report that phenotypically similar diseases are connected by the evolutionary constraints on human disease genes. Human disease groups can be classified into slo...

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Detalles Bibliográficos
Autores principales: Park, Solip, Yang, Jae-Seong, Kim, Jinho, Shin, Young-Eun, Hwang, Jihye, Park, Juyong, Jang, Sung Key, Kim, Sanguk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477654/
https://www.ncbi.nlm.nih.gov/pubmed/23091697
http://dx.doi.org/10.1038/srep00757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477654/
https://www.ncbi.nlm.nih.gov/pubmed/23091697
http://dx.doi.org/10.1038/srep00757

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